GPR179 - G protein-coupled receptor 179 Gene

Also Known as CSNB1E; GPR158L; GPR158L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 440435

About GPR179

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,324,571-38,343,956 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 196 orthologues, 1 paralogue and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E. [provided by RefSeq, Apr 2012]

GPR179 Products (1)

mRNA	Protein	Name
NM_001004334.4	NP_001004334.3	probable G-protein coupled receptor 179 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30282023	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in visual perception	IMP IMP: Inferred from mutant phenotype	22325362	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in dendrite	IDA IDA: Inferred from direct assay	24084093	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR179 Protein Structure

7tm_3

0
400
800
1200
1600
2000
2367 a.a.

Protein Preferred Names	Protein Names
probable G-protein coupled receptor 179	GPR158-like 1

GPR179 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	GPR179	Q6PRD1	Egflam	Mus musculus	Q4VBE4	Pull Down	30282023
Cross	GPR179	Q6PRD1	Egflam	Mus musculus	Q4VBE4	Anti Tag CoIP	30282023
Intra	GPR179	Q6PRD1	EGFLAM	Homo sapiens	Q63HQ2	IF	30282023
Intra	GPR179	Q6PRD1	EGFLAM	Homo sapiens	Q63HQ2	Anti Tag CoIP	30282023
Intra	GPR179	Q6PRD1	GPC5	Homo sapiens	P78333	Anti Tag CoIP	30282023
Intra	GPR179	Q6PRD1	SDC4	Homo sapiens	P31431	Anti Tag CoIP	30282023
Intra	GPR179	Q6PRD1	GPC1	Homo sapiens	P35052	Anti Tag CoIP	30282023

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Night Blindness, Congenital Stationary, Type 1e	CSNB1E Congenital Stationary Night Blindness 1e Csnb, Complete, Autosomal Recessive Night Blindness, Congenital Stationary , 1e, Autosomal Recessive Congenital Stationary Night Blindness 1e Autosomal Recessive Night Blindness, Congenital Stationary, 1e Complete Autosomal Recessive Csnb Csnb1 Night Blindness, Congenital Stationary, Type 1 Blindness, Night, Stationary, Congenital, Type 1e
Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary Congenital Essential Nyctalopia Oguchi Disease Blindness, Night, Stationary, Congenital
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Night Blindness	Nyctalopia
Abnormal Threshold Of Rods	Abnormal Dark Adaptation Curve
Night Blindness, Congenital Stationary, Type 1b	Congenital Stationary Night Blindness 1b CSNB1B Night Blindness, Congenital Stationary, Complete, Autosomal Recessive Csnb, Complete, Autosomal Recessive Night Blindness, Congenital Stationary , 1b, Autosomal Recessive Autosomal Recessive Complete Congenital Stationary Night Blindness Congenital Stationary Night Blindness 1b Autosomal Recessive Night Blindness, Congenital Stationary, 1b Complete Autosomal Recessive Csnb Complete Congenital Stationary Night Blindness Autosomal Recessive Blindness, Night, Stationary, Congenital, Type 1b
Cone-Rod Dystrophy 15	Retinitis Pigmentosa 65 CORD15 Dystrophy, Cone-Rod, Type 15
Night Blindness, Congenital Stationary, Type 1c	Congenital Stationary Night Blindness 1c CSNB1C Csnb, Complete, Autosomal Recessive Night Blindness, Congenital Stationary , 1c, Autosomal Recessive Congenital Stationary Night Blindness 1c Autosomal Recessive Night Blindness, Congenital Stationary, 1c Complete Autosomal Recessive Csnb Night Blindness, Congenital Stationary, Type Ic Blindness, Night, Stationary, Congenital, Type 1c
Night Blindness, Congenital Stationary, Type 1a	Congenital Stationary Night Blindness 1a CSNB1A Hemeralopia-Myopia Myopia-Night Blindness Night Blindness, Congenital Stationary , 1a, X-Linked Congenital Stationary Night Blindness With Myopia Csnb, Complete, X-Linked Night Blindness, Congenital Stationary, With Myopia Nbm1 Complete Csnb X-Linked Congenital Stationary Night Blindness 1a X-Linked Nbmi Night Blindness, Congenital Stationary, 1a Complete X-Linked Csnb Nyctalopia Xlcsnb X-Linked Congenital Stationary Night Blindness Blindness, Night, Stationary, Congenital, Type 1a Night Blindness X-Linked Csnb Night Blindness, Congenital Stationary, Type 2a
Retinitis Pigmentosa 86	RP86 Retinitis Pigmentosa, Type 86
Fundus Albipunctatus	Retinitis Punctata Albescens Pigmentary Retinal Dystrophy RPA Albipunctate Retinal Dystrophy Lauber'S Disease FALBI Fa
Refractive Error	Refractive Errors
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05686	GPR179 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GPR179	MGD	MGI:2443409
Felis catus	GPR179	VGNC	VGNC:62689
Macaca mulatta	GPR179	VGNC	VGNC:73043
Bos taurus	GPR179	VGNC	VGNC:29573
Rattus norvegicus	GPR179	RGD	RGD:1560033
Canis familiaris	GPR179	VGNC	VGNC:41419
Others	GPR179	NCBI