Egflam - EGF-like, fibronectin type III and laminin G domains Gene

Also Known as 5930412K08

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268780

Summary

Enables glycosaminoglycan binding activity. Acts upstream of or within extracellular matrix organization; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; and positive regulation of cell-substrate adhesion. Located in basement membrane and interstitial matrix. Is expressed in hair follicle and rib. Orthologous to human EGFLAM (EGF like, fibronectin type III and laminin G domains). [provided by Alliance of Genome Resources, Apr 2022]

Egflam Products (3)

mRNA Protein Name
NM_001289496.1 NP_001276425.1 pikachurin isoform 1 precursor
NM_001289498.1 NP_001276427.1 pikachurin isoform 3
NM_178748.6 NP_848863.1 pikachurin isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycosaminoglycan binding IDA
IDA: Inferred from direct assay
18757743 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18641643 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
18757743 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
18757743 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
18757743 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
18757743 MGI
located in interstitial matrix IDA
IDA: Inferred from direct assay
18757743 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
21129441 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pikachurin

  • EGF-like, fibronectin type-III and laminin G-like domain-containing protein

  • nectican

Egflam Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Egflam Q4VBE4 Q62165-PRO_0000021067 Mus musculus Q62165-PRO_0000021067
Pull Down
18641643
Cross
Egflam Q4VBE4 GPR179 Homo sapiens Q6PRD1
PLA
30282023
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04208 EGFLAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21850 Egflam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28367 Egflam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Egflam NCBI NCBI:133584