DNAJC11 - DnaJ heat shock protein family (Hsp40) member C11 Gene

Also Known as dJ126A5.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55735

About DNAJC11

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,634,170-6,701,816 (from NCBI)

This gene has 25 transcripts (splice variants), 281 orthologues and 20 paralogues. Ubiquitous expression in kidney (RPKM 23.0), colon (RPKM 15.3) and 25 other tissues.

Summary

Involved in cristae formation. Located in mitochondrial outer membrane and nuclear speck. Part of MIB complex. Colocalizes with MICOS complex and SAM complex. [provided by Alliance of Genome Resources, Apr 2022]

DNAJC11 Products (1)

mRNA Protein Name
NM_018198.4 NP_060668.2 dnaJ homolog subfamily C member 11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
Biological Process GO Annotation Evidence References Source
involved in cristae formation IMP
IMP: Inferred from mutant phenotype
25111180 GOA
Cellular Component GO Annotation Evidence References Source
part of MICOS complex IDA
IDA: Inferred from direct assay
25997101 GOA
part of SAM complex IDA
IDA: Inferred from direct assay
25997101 GOA
located in mitochondrial outer membrane IMP
IMP: Inferred from mutant phenotype
25111180 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
25997101 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC11 Protein Structure

DnaJ

DnaJ: DnaJ domain (14 - 79)

DUF3395

DUF3395: Domain of unknown function (DUF3395) (410 - 549)

  • 0
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  • 200
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  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily C member 11

  • DnaJ (Hsp40) homolog, subfamily C, member 11

DNAJC11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNAJC11 Q9NVH1 PM20D2 Homo sapiens Q8IYS1
Y2H Array
32296183
Intra
DNAJC11 Q9NVH1 PM20D2 Homo sapiens Q8IYS1
Y2H Prey Pooling
32296183
Intra
DNAJC11 Q9NVH1 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
DNAJC11 Q9NVH1 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
DNAJC11 Q9NVH1 HTT Homo sapiens P42858
Y2H
17500595
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Seckel Syndrome 6

  • SCKL6

  • Seckel Syndrome, Type 6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03874 DNAJC11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22000 Dnajc11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28517 Dnajc11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DNAJC11 VGNC VGNC:99893
Canis familiaris DNAJC11 VGNC VGNC:53345
Rattus norvegicus DNAJC11 RGD RGD:1307731
Mus musculus DNAJC11 MGD MGI:2443386
Felis catus DNAJC11 VGNC VGNC:80185
Others DNAJC11 NCBI