3055593-63-7
Chemical Structure
MS99-β-Gal
Synonym(s): Gal-MS99
- CAS No.: 3055593-63-7
- Formula:C78H96ClN9O20S2
- Molecular Weight:1579.23
InChIKey: BUVKYQBXYNGPRB-FRPMDCEFSA-N
SMILES: CC(O[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OC2=CC=C(C=C2)COC(O[C@H]3CN([C@@H](C3)C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)C([C@H](C(C)(C)C)NC(CCCC(N6CCC(CC6)C7=CC(OC(C)C)=C(NC8=NC=C(C(NC9=C(S(=O)(C(C)C)=O)C=CC=C9)=N8)Cl)C=C7C)=O)=O)=O)=O)COC(C)=O)OC(C)=O)OC(C)=O)=O
Biological Activity: MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC50 of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC50 = 2.162 μM). MS99-β-Gal can be used for the research of cancer[1].
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MS99-β-Gal | MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC50 of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC50 = 2.162 μM). MS99-β-Gal can be used for the research of cancer. | |||||||||||||||||||||
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Keywords
