MS99-β-Gal
MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC50 of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC50 = 2.162 μM). MS99-β-Gal can be used for the research of cancer.
(Pink: NPM-ALK ligand (HY-15656); Blue: VHL ligand (HY-112078); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3055593-63-7
- Formula: C78H96ClN9O20S2
- Molecular Weight:1579.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KARPAS-299 | IC50 |
2162 nM
Compound: Gal-MS99
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Antiproliferative activity against human normal (non-senescent) KARPAS-299 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human normal (non-senescent) KARPAS-299 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 38635879] |
Chemical Information
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CAS No. 3055593-63-7
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Molecular Weight 1579.23
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Formula C78H96ClN9O20S2
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SMILES
CC(O[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OC2=CC=C(C=C2)COC(O[C@H]3CN([C@@H](C3)C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)C([C@H](C(C)(C)C)NC(CCCC(N6CCC(CC6)C7=CC(OC(C)C)=C(NC8=NC=C(C(NC9=C(S(=O)(C(C)C)=O)C=CC=C9)=N8)Cl)C=C7C)=O)=O)=O)=O)COC(C)=O)OC(C)=O)OC(C)=O)=O
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Synonyms
Gal-MS99
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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