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Art. -Nr.: HY-177945

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MS99-β-Gal

Name: MS99-β-Gal
Brand: MedChemExpress
SKU: HY-177945
Availability: PreOrder

(Synonyms: Gal-MS99)

MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC₅₀ of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC₅₀ = 2.162 μM). MS99-β-Gal can be used for the research of cancer.
(Pink: NPM-ALK ligand (HY-15656); Blue: VHL ligand (HY-112078); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3055593-63-7
Formel: C₇₈H₉₆ClN₉O₂₀S₂
Molecular Weight:1579.23

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

MS99-β-Gal Chemical Structure

CAS. Nr.: 3055593-63-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC₅₀ of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC₅₀ = 2.162 μM). MS99-β-Gal can be used for the research of cancer^[1]. (Pink: NPM-ALK ligand (HY-15656); Blue: VHL ligand (HY-112078); Black: linker).

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-299	IC₅₀	2162 nM Compound: Gal-MS99	Antiproliferative activity against human normal (non-senescent) KARPAS-299 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human normal (non-senescent) KARPAS-299 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 38635879]

Chemical Information

CAS. Nr. 3055593-63-7
Molecular Weight 1579.23
Formel C₇₈H₉₆ClN₉O₂₀S₂
SMILES

CC(O[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OC2=CC=C(C=C2)COC(O[C@H]3CN([C@@H](C3)C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)C([C@H](C(C)(C)C)NC(CCCC(N6CCC(CC6)C7=CC(OC(C)C)=C(NC8=NC=C(C(NC9=C(S(=O)(C(C)C)=O)C=CC=C9)=N8)Cl)C=C7C)=O)=O)=O)=O)COC(C)=O)OC(C)=O)OC(C)=O)=O
Synonyms

Gal-MS99
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chang M, et al. Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs. J Med Chem. 2024 May 9;67(9):7301-7311. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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