MFSD10 - major facilitator superfamily domain containing 10 Gene

Also Known as TETRAN; TETTRAN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10227

About MFSD10

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,930,567-2,934,825 (from NCBI)

This gene has 11 transcripts (splice variants), 571 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 36.8), spleen (RPKM 13.5) and 24 other tissues.

Summary

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

MFSD10 Products (4)

mRNA Protein Name
NM_001120.5 NP_001111.3 major facilitator superfamily domain-containing protein 10 isoform a
NM_001146069.2 NP_001139541.1 major facilitator superfamily domain-containing protein 10 isoform a
NM_001363679.2 NP_001350608.1 major facilitator superfamily domain-containing protein 10 isoform b
NM_001410703.1 NP_001397632.1 major facilitator superfamily domain-containing protein 10 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables organic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
18638446 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within sodium-independent organic anion transport IDA
IDA: Inferred from direct assay
18638446 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
18638446 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MFSD10 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (28 - 412)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 455 a.a.
Protein Preferred Names Protein Names

major facilitator superfamily domain-containing protein 10

  • tetracycline transporter-like protein

MFSD10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MFSD10 Q14728 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
MFSD10 Q14728 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
MFSD10 Q14728 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
MFSD10 Q14728 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
MFSD10 Q14728 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
MFSD10 Q14728 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mahvash Disease

  • Gcgr-Related Hyperglucagonemia

  • MVAH

  • Alpha-Cell Hyperplasia With Glucagonemia

  • Nesidioblastosis, Alpha Cell Hyperplasia, Microglucagonoma, And Nonfunctioning Islet Cell Tumor

  • Nesidioblastosis Alpha Cell Hyperplasia Microglucagonoma And Nonfunctioning Islet Cell Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08388 MFSD10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MFSD10 VGNC VGNC:63475
Canis familiaris MFSD10 VGNC VGNC:43196
Rattus norvegicus MFSD10 RGD RGD:1311900
Bos taurus MFSD10 VGNC VGNC:31432
Macaca mulatta MFSD10 VGNC VGNC:100247
Mus musculus MFSD10 MGD MGI:1915544
Others MFSD10 NCBI