Gabrb1 - gamma-aminobutyric acid type A receptor subunit beta1 Gene

Also Known as GARB1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25450

Summary

Enables GABA Receptor binding activity; GABA-A receptor activity; and ion channel activity. Involved in several processes, including cellular response to histamine; central nervous system neuron development; and response to progesterone. Located in several cellular components, including cytoplasm; dendrite; and nuclear envelope. Is integral component of plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 45. Orthologous to human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1). [provided by Alliance of Genome Resources, Apr 2022]

Gabrb1 Products (1)

mRNA Protein Name
NM_012956.2 NP_037088.1 gamma-aminobutyric acid receptor subunit beta-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GABA receptor binding IPI
IPI: Inferred from physical interaction
17959749 RGD
enables GABA-A receptor activity IDA
IDA: Inferred from direct assay
2548852 RGD
enables GABA-A receptor activity IMP
IMP: Inferred from mutant phenotype
2540033 RGD
enables ligand-gated monoatomic ion channel activity IMP
IMP: Inferred from mutant phenotype
2540033 RGD
enables monoatomic anion channel activity IDA
IDA: Inferred from direct assay
2479580 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
16469775 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
16469775 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to histamine IDA
IDA: Inferred from direct assay
18281286 RGD
involved in central nervous system neuron development IEP
IEP: Inferred from expression pattern
15158077 RGD
involved in monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
2540033 RGD
involved in ovulation cycle IEP
IEP: Inferred from expression pattern
16226387 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
15834956 RGD
involved in response to toxic substance IDA
IDA: Inferred from direct assay
2479580 RGD
Cellular Component GO Annotation Evidence References Source
part of GABA-A receptor complex IMP
IMP: Inferred from mutant phenotype
2540033 RGD
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
16469775 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
15174078 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16226387 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
20511229 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
2540033 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
15174078 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
15174078 RGD
part of receptor complex IDA
IDA: Inferred from direct assay
17959749 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit beta-1

  • GABA(A) receptor subunit beta-1

  • Gamma-aminobutyric acid receptor beta 1

  • gamma-aminobutyric acid (GABA) A receptor, beta 1

  • gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1

  • gamma-aminobutyric acid type A receptor beta 1 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05215 GABRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabrb1 NCBI NCBI:2560