Homer2 - homer scaffolding protein 2 Gene

Also Known as CPD; Vesl-2; 9330120H11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26557

Summary

Enables actin binding activity and synaptic receptor adaptor activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including behavioral response to cocaine; calcium-mediated signaling using intracellular calcium source; and chemical homeostasis within a tissue. Located in several cellular components, including apical part of cell; postsynaptic density; and stereocilium tip. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Homer2 Products (3)

mRNA Protein Name
NM_001164086.1 NP_001157558.1 homer protein homolog 2 isoform 2
NM_001164087.1 NP_001157559.1 homer protein homolog 2 isoform 3
NM_011983.2 NP_036113.1 homer protein homolog 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
10493740 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9808458 MGI
enables synaptic receptor adaptor activity IDA
IDA: Inferred from direct assay
10493740 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
15294147 MGI
acts upstream of or within calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
12860966 MGI
acts upstream of or within regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12860966 MGI
involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
25816005 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
12860966 MGI
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
10493740 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24530450 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
24530450 MGI
located in stereocilium tip IDA
IDA: Inferred from direct assay
25816005 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homer protein homolog 2

  • VASP/Ena-related gene up-regulated during seizure and LTP 2

  • cupidin

  • homer homolog 2

  • homer, neuronal immediate early gene, 2

  • homer-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06284 HOMER2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Homer2 NCBI NCBI:9455