HOMER2 - homer scaffold protein 2 Gene

Homo sapiens

Also known as CPD; ACPD; DFNA68; VESL-2; HOMER-2

Gene ID: 9455 | Gene type: protein coding

About HOMER2

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:82,834,661-82,986,157 (from NCBI)

This gene has 10 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in prostate (RPKM 9.3), pancreas (RPKM 6.8) and 16 other tissues.

Summary

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]

HOMER2 Products(2)

mRNA	Protein	Name
NM_004839.4	NP_004830.2	homer protein homolog 2 isoform 1
NM_199330.3	NP_955362.1	homer protein homolog 2 isoform 2

HOMER2 Protein Structure

WH1

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

homer protein homolog 2

cupidin

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 68

DFNA68	Autosomal Dominant Nonsyndromic Deafness 68
Autosomal Dominant Deafness 68	Deafness, Autosomal Dominant, 68

Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Isolated Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna	Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna

Deafness, Autosomal Recessive 104

DFNB104	Autosomal Recessive Nonsyndromic Deafness 104
Autosomal Recessive Deafness 104	Deafness, Autosomal Recessive, 104
Deafness, Autosomal Recessive, Type 104

Achilles Bursitis

Achilles Bursitis Or Tendinitis	Capped Hock
Haglund'S Deformity	Haglund'S Disease
Osteochondritis Of The Talus

Deafness, Autosomal Dominant 67

DFNA67	Autosomal Dominant Nonsyndromic Deafness 67
Autosomal Dominant Deafness 67	Deafness, Autosomal Dominant, 67
Deafness, Autosomal Dominant, Type 67

Diamond-Blackfan Anemia 4

DBA4	Rps17-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 4

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06284	HOMER2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HOMER2	VGNC	VGNC:73406
Bos taurus	HOMER2	VGNC	VGNC:29902
Mus musculus	HOMER2	MGD	MGI:1347354
Felis catus	HOMER2	VGNC	VGNC:62831
Rattus norvegicus	HOMER2	RGD	RGD:620705

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