HOMER2 - homer scaffold protein 2 Gene

Also Known as CPD; ACPD; DFNA68; VESL-2; HOMER-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9455

About HOMER2

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:82,834,661-82,986,157 (from NCBI)

This gene has 10 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in prostate (RPKM 9.3), pancreas (RPKM 6.8) and 16 other tissues.

Summary

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]

HOMER2 Products (2)

mRNA	Protein	Name
NM_004839.4	NP_004830.2	homer protein homolog 2 isoform 1
NM_199330.3	NP_955362.1	homer protein homolog 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18218901	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	18218901	GOA
involved in negative regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	18218901	GOA
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	25816005	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25816005	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOMER2 Protein Structure

WH1

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
homer protein homolog 2	cupidin

HOMER2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HOMER2	Q9NSB8	RNF41	Homo sapiens	Q9H4P4	Validated Y2H	25416956
Intra	HOMER2	Q9NSB8	RNF41	Homo sapiens	Q9H4P4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Dominant 68	DFNA68 Autosomal Dominant Nonsyndromic Deafness 68 Autosomal Dominant Deafness 68 Deafness, Autosomal Dominant, 68
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Deafness Type Dfna Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna Autosomal Dominant Isolated Sensorineural Deafness Type Dfna Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Deafness, Autosomal Recessive 104	DFNB104 Autosomal Recessive Nonsyndromic Deafness 104 Autosomal Recessive Deafness 104 Deafness, Autosomal Recessive, 104 Deafness, Autosomal Recessive, Type 104
Achilles Bursitis	Achilles Bursitis Or Tendinitis Capped Hock Haglund'S Deformity Haglund'S Disease Osteochondritis Of The Talus
Deafness, Autosomal Dominant 67	DFNA67 Autosomal Dominant Nonsyndromic Deafness 67 Autosomal Dominant Deafness 67 Deafness, Autosomal Dominant, 67 Deafness, Autosomal Dominant, Type 67
Diamond-Blackfan Anemia 4	DBA4 Rps17-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 4
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06284	HOMER2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HOMER2	VGNC	VGNC:73406
Bos taurus	HOMER2	VGNC	VGNC:29902
Mus musculus	HOMER2	MGD	MGI:1347354
Felis catus	HOMER2	VGNC	VGNC:62831
Rattus norvegicus	HOMER2	RGD	RGD:620705
Others	HOMER2	NCBI