GNAZ - G protein subunit alpha z Gene

Also Known as HG1H; gz-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2781

About GNAZ

Cytogenetic location: 22q11.22-q11.23 Genomic coordinates (GRCh38): 22:23,070,519-23,125,032 (from NCBI)

This gene has 3 transcripts (splice variants), 211 orthologues and 15 paralogues. Broad expression in brain (RPKM 3.2), gall bladder (RPKM 1.3) and 16 other tissues.

Summary

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

GNAZ Products (1)

mRNA Protein Name
NM_002073.4 NP_002064.1 guanine nucleotide-binding protein G(z) subunit alpha

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28891236 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNAZ Protein Structure

G-alpha

G-alpha: G-protein alpha subunit (4 - 344)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(z) subunit alpha

  • g(x) alpha chain

Recombinant GNAZ Proteins

Cat. No. Product Name Accession Purity
HY-P72208 GNAZ Protein, Human (His-SUMO) P19086 (G2-C355) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pertussis

  • Whooping Cough

  • Bordetella Infections

  • Bordetella Infection

  • Bordetella Pertussis Infection

  • Wc - Whooping Cough

  • Whooping Cough Due To Unspecified Organism

  • Bordetellosis

  • Tussis Convulsiva

  • Whooping Cough, Unspecified Organism

  • Wc - [Whooping Cough]

  • Whooping Cough Due To B. Parapertussis

  • Infection Due To Bordetella Parapertussis
Night Blindness

  • Nyctalopia
Thrombocytopenia-Absent Radius Syndrome

  • Tar Syndrome

  • Radial Aplasia-Thrombocytopenia Syndrome

  • Absent Radii And Thrombocytopenia

  • TAR

  • Chromosome 1q21.1 Deletion Syndrome, 200-Kb

  • Thrombocytopenia Absent Radius Syndrome

  • Thrombocytopenia Absent Radii

  • Chromosome 1q21.1 Deletion Syndrome

  • Thrombocytopenia With Absent Radii Syndrome

  • Radial Aplasia-Amegakaryocytic Thrombocytopenia
Achromatopsia

  • Achm

  • Rod Monochromatism

  • Total Color Blindness

  • Rod Monochromacy

  • Monochromatism

  • Achromatism

  • Complete Or Incomplete Color Blindness

  • Pingelapese Blindness

  • Achromatopsia 1

  • Achromatopsia 2

  • Achromatopsia 3
Ulna And Fibula, Absence Of, With Severe Limb Deficiency

  • Schinzel Phocomelia Syndrome

  • Aarrs

  • Limb/Pelvis-Hypoplasia/Aplasia Syndrome

  • LPHAS

  • Schinzel Type Phocomelia

  • Absence Of Ulna And Fibula With Severe Limb Deficiency

  • Al-Awadi/Raas-Rothschild Syndrome

  • Al Awadi-Raas-Rothschild Syndrome

  • Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

  • Aplasia/Hypoplasia Of Limbs And Pelvis

  • Congenital Absence Of Ulna And Fibula

  • Severe Limb Deficit

  • Phocomelia, Schinzel Type

  • Al-Awadi-Raas-Rothschild Syndrome

  • Ulna And Fibula Absence Of With Severe Limb Deficiency

  • Limb Pelvis Hypoplasia Aplasia Syndrome

  • Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome

  • Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Pancreas, Annular

  • Annular Pancreas

  • Pancreas Annulare

  • Congenital Annular Pancreas
Usher Syndrome, Type Id

  • Usher Syndrome Type 1d

  • USH1D

  • Usher Syndrome, Type 1d

  • Usher Syndrome Type Id

  • Usher Syndrome, Type Id/F, Digenic

  • Usher Syndrome, Type 1d/F Digenic

  • Usher Syndrome 1d

  • Usher'S Syndrome Type 1d

  • Usher Syndrome 1d/F

  • USH1DF

  • Ush1d/F

  • Usher'S Syndrome Type 1h

  • Usher Syndrome 1h

  • Usher Syndrome Type Ih

  • Usher Syndrome, Type 1d/F
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05544 GNAZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19138 Gnaz Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25628 Gnaz Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GNAZ RGD RGD:2717
Bos taurus GNAZ VGNC VGNC:58379
Canis familiaris GNAZ VGNC VGNC:41310
Felis catus GNAZ VGNC VGNC:62619
Macaca mulatta GNAZ VGNC VGNC:73094
Mus musculus GNAZ MGD MGI:95780
Others GNAZ NCBI