GNAZ Protein, Human (His-SUMO)
GNAZ proteins are members of G proteins that are crucial in regulating or transducing signals in a variety of transmembrane signaling systems. G proteins have three units, α, β, and γ, and play a key role in signal transmission across cell membranes. GNAZ Protein, Human (His-SUMO) is the recombinant human-derived GNAZ protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
GNAZ proteins are members of G proteins that are crucial in regulating or transducing signals in a variety of transmembrane signaling systems. G proteins have three units, α, β, and γ, and play a key role in signal transmission across cell membranes. GNAZ Protein, Human (His-SUMO) is the recombinant human-derived GNAZ protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
GNAZ, a member of guanine nucleotide-binding proteins (G proteins), functions as a critical modulator or transducer in diverse transmembrane signaling systems. Comprising three units—alpha, beta, and gamma—G proteins play a pivotal role in transmitting signals across cell membranes. The alpha chain of GNAZ harbors the guanine nucleotide binding site, essential for its regulatory activities. Additionally, GNAZ interacts with ADGRB2, suggesting its involvement in specific signaling pathways and cellular processes.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His;N-SUMO
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Accession
P19086 (G2-C355)
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Molecular Construction
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N-term
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6*His-SUMO
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GNAZ (G2-C355)
Accession # P19086 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
GNAZ; Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide; G Protein Subunit Alpha Z; Heterotrimeric Guanine Nucleotide-Binding Protein 1H; Guanine Nucleotide-Binding Protein G(Z) Subunit Alpha; Transducin Alpha; G(X) Alpha Chain; HG1H; Gz
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AA Sequence
GCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNSGKSTIVKQMKIIHSGGFNLEACKEYKPLIIYNAIDSLTRIIRALAALRIDFHNPDRAYDAVQLFALTGPAESKGEITPELLGVMRRLWADPGAQACFSRSSEYHLEDNAAYYLNDLERIAAADYIPTVEDILRSRDMTTGIVENKFTFKELTFKMVDVGGQRSERKKWIHCFEGVTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNWFINTSLILFLNKKDLLAEKIRRIPLTICFPEYKGQNTYEEAAVYIQRQFEDLNRNKETKEIYSHFTCATDTSNIQFVFDAVTDVIIQNNLKYIGLC
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Predicted Molecular Mass
56.8 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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