KAT2B - lysine acetyltransferase 2B Gene

Also Known as Pcaf; AABR07066180.1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 301164

About KAT2B

Primary_assembly 9: 6,562,288-6,667,064 forward strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 226 orthologues, 11 paralogues and is associated with 4 phenotypes. Biased expression in Muscle (RPKM 351.2), Heart (RPKM 315.7) and 9 other tissues.

Summary

Enables chromatin binding activity; Histone Acetyltransferase binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; positive regulation of chromatin binding activity; and positive regulation of histone acetylation. Located in chromatin; cytosol; and nucleus. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]

KAT2B Products (5)

mRNA Protein Name
XM_039084397.1 XP_038940325.1 histone acetyltransferase KAT2B isoform X2
XM_039084398.1 XP_038940326.1 histone acetyltransferase KAT2B isoform X3
XM_039084400.1 XP_038940328.1 histone acetyltransferase KAT2B isoform X5
XM_039084399.1 XP_038940327.1 histone acetyltransferase KAT2B isoform X4
XM_039084396.1 XP_038940324.1 histone acetyltransferase KAT2B isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
20870727 RGD
enables histone acetyltransferase binding IPI
IPI: Inferred from physical interaction
20870727 RGD
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
24526703 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18042454 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IEP
IEP: Inferred from expression pattern
18945670 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
20870727 RGD
involved in memory IEP
IEP: Inferred from expression pattern
20811339 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
20094059 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20870727 RGD
involved in protein acetylation IMP
IMP: Inferred from mutant phenotype
22859492 RGD
involved in vasodilation IDA
IDA: Inferred from direct assay
22859492 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
20870727 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KAT2B Protein Structure

PCAF_N

PCAF_N: pfam06466 (55 - 306)

COG5076

COG5076: cl34891 (467 - 806)

Bromo_gcn5_like

Bromo_gcn5_like: cd05509 (707 - 806)

  • 0
  • 200
  • 400
  • 600
  • 813 a.a.
Protein Preferred Names Protein Names

histone acetyltransferase KAT2B

  • K(lysine) acetyltransferase 2B

  • p300/CBP-associated factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W015239 KAT8-IN-1 99.61% Unkown
HY-173158 AUR1545 Inhibitor 99.58% Unkown
HY-122822 GSK699 98.80% Unkown
HY-168428 CHI-KAT8i5 98.00% Unkown
HY-181695 PROTAC KAT2A/B degrader-1 Degrader / Unkown
HY-RS07077 KAT2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07078 Kat2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07079 KAT2B Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens KAT2B NCBI NCBI:8850