CYLD - Cyld CYLD lysine 63 deubiquitinase Gene

Also Known as Rp1; Rp1h; LRRGT00003

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 312937

Summary

Predicted to enable several functions, including Deubiquitinase activity; proline-rich region binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including protein deubiquitination; regulation of organelle organization; and regulation of signal transduction. Predicted to act upstream of or within several processes, including positive regulation of T cell receptor signaling pathway; regulation of lymphocyte differentiation; and ripoptosome assembly involved in necroptotic process. Predicted to be located in ciliary tip and microtubule Cytoskeleton. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytosol. Predicted to colocalize with cytoplasmic microtubule and midbody. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 Deubiquitinase). [provided by Alliance of Genome Resources, Apr 2022]

CYLD Products (1)

mRNA Protein Name
NM_001017380.1 NP_001017380.1 ubiquitin carboxyl-terminal hydrolase CYLD

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
28973854 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
28973854 RGD
involved in regulation protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
28973854 RGD
involved in regulation protein catabolic process at postsynapse IEP
IEP: Inferred from expression pattern
28973854 RGD
involved in regulation protein catabolic process at postsynapse IMP
IMP: Inferred from mutant phenotype
28973854 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24614225 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28973854 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
24614225 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase CYLD

  • 40S ribosomal protein S3a-like

  • cylindromatosis (turban tumor syndrome)

  • deubiquitinating enzyme CYLD

  • probable ubiquitin carboxyl-terminal hydrolase CYLD

  • probable ubiquitin carboxyl-terminal hydrolase CYLD-like

  • retinitis pigmentosa 1 homolog

  • ubiquitin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-176426 Subquinocin 99.83% Phase 4

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19704 Pegcantratinib Antagonist / Unkown
HY-RS03433 CYLD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17882 Cyld Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24351 Cyld Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CYLD NCBI NCBI:1540