Flot2 - flotillin 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83764

Summary

Enables ionotropic glutamate receptor binding activity and protease binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of NF-kappaB transcription factor activity; and protein localization to cell periphery. Located in caveola. Part of flotillin complex. Is active in glutamatergic synapse. Is anchored component of presynaptic active zone membrane. Orthologous to human FLOT2 (flotillin 2). [provided by Alliance of Genome Resources, Apr 2022]

Flot2 Products (3)

mRNA Protein Name
NM_001270800.1 NP_001257729.1 flotillin-2 isoform 2
NM_001270801.1 NP_001257730.1 flotillin-2 isoform 3
NM_031830.2 NP_114018.1 flotillin-2 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
19298817 RGD
enables protease binding IPI
IPI: Inferred from physical interaction
24612608 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19298817 RGD
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
9858255 RGD
part of flotillin complex IDA
IDA: Inferred from direct assay
9858255 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23622064 RGD
is active in presynaptic active zone membrane EXP
EXP: Inferred from Experiment
23622064 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
23622064 RGD
is active in synapse EXP
EXP: Inferred from Experiment
21797867 RGD
is active in synapse IDA
IDA: Inferred from direct assay
21797867 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

flotillin-2

  • REG-1

  • reggie-1

  • reggie1-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04983 FLOT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Flot2 NCBI NCBI:2319