FLOT2 - flotillin 2 Gene

Also Known as ESA; ECS1; ESA1; ECS-1; M17S1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2319

About FLOT2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,879,339-28,897,733 (from NCBI)

This gene has 12 transcripts (splice variants), 279 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 42.8), spleen (RPKM 42.2) and 25 other tissues.

Summary

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in Neuronal Signaling. [provided by RefSeq, Jul 2008]

FLOT2 Products (2)

mRNA	Protein	Name
NM_001330170.2	NP_001317099.1	flotillin-2 isoform 2
NM_004475.3	NP_004466.2	flotillin-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17113085	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	24612608	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24612608	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	23319823	GOA
involved in positive regulation of establishment of T cell polarity	IMP IMP: Inferred from mutant phenotype	21696602	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	24612608	GOA
involved in protein localization to plasma membrane raft	IMP IMP: Inferred from mutant phenotype	21696602	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	24612608	GOA
NOT involved in regulation of heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in regulation of myoblast differentiation	IEP IEP: Inferred from expression pattern	25105415	GOA
NOT involved in regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	25204797	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in adherens junction	IDA IDA: Inferred from direct assay	24046456	GOA
NOT located in apical plasma membrane	IDA IDA: Inferred from direct assay	23983584	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	23983584	GOA
located in caveola	IDA IDA: Inferred from direct assay	24013648	GOA
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	23983584	GOA
colocalizes with cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	24046456	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	23983584	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	20682791	GOA
located in endosome	IDA IDA: Inferred from direct assay	20682791	GOA
part of flotillin complex	IDA IDA: Inferred from direct assay	21696602	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	24046456	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21119006	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	21696602	GOA
located in uropod	IDA IDA: Inferred from direct assay	21696602	GOA
located in vesicle	IDA IDA: Inferred from direct assay	21119006	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLOT2 Protein Structure

Band_7

0
100
200
300
400
428 a.a.

Protein Preferred Names	Protein Names
flotillin-2	Flotillin 2 (epidermal surface antigen 1)

FLOT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	FLOT2	Q14254	FLOT1	Homo sapiens	O75955	Confocal	24167781
Intra	FLOT2	Q14254	FLOT1	Homo sapiens	O75955	Crosslink	30021884
Intra	FLOT2	Q14254	FLOT1	Homo sapiens	O75955	Far-WB	17113085
Intra	FLOT2	Q14254	SNCG	Homo sapiens	Q6FHG5	Anti Bait CoIP	25229320

Cross: Cross-species interaction Intra: Intraspecies interaction

FLOT2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81694	Flotillin 2 Antibody (YA1439)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS04983	FLOT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FLOT2	RGD	RGD:70993
Mus musculus	FLOT2	MGD	MGI:103309
Bos taurus	FLOT2	VGNC	VGNC:29037
Felis catus	FLOT2	VGNC	VGNC:62295
Others	FLOT2	NCBI