3 Results for "

rexinoid

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "rexinoid" in MCE Product Catalog:

Fluorobexarotene
Fluorobexarotene
0 Images
Cat. No.: HY-108525
CAS No.: 1190848-23-7
Purity:  99.48%
Target:  

RAR/RXR

Research Areas:  

Cancer

Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene .
BRF110
BRF110
0 Images
Cat. No.: HY-138967
CAS No.: 2095489-35-1
Target:  

Nuclear Hormone Receptor 4A/NR4A RAR/RXR

Research Areas:  

Neurological Disease

BRF110 is the selective, orally active rexinoid for Nurr1-RXRα, that selectively activates the Nurr1-RXRα heterodimer with an EC50 of 0.9 μM in SH-SY5Y. BRF110 upregulates the expression of BDNF, exhibits neuroprotective activity against MPP+ induced toxicity. BRF110 can cross blood-brain barrier .
9-cis-UAB30
9-cis-UAB30
0 Images
Cat. No.: HY-129108
CAS No.: 205252-57-9
Synonyms: (9Z)-UAB-30
Target:  

Oct3/4 Microtubule/Tubulin E1/E2/E3 Enzyme Proteasome

Research Areas:  

Neurological Disease Cancer

9-cis-UAB30 is a rexinoid agonist. 9-cis-UAB30 significantly decreases the proliferation, viability, and motility of both patient-derived xenografts (PDXs). 9-cis-UAB30 induced cell-cycle arrest as demonstrated by the significant increase in the percentage of cells in G1 and a decrease in the percentage of cells in S phase by downregulating SKP2 and/or 20S proteasome activity, which leads to increased p27kip1 protein stability. 9-cis-UAB30 downregulates the abundance of stem cell marker mRNAs (Oct4, Nanog, Sox2, nestin) and upregulates the abundance of differentiation marker mRNAs (β3-tubulin, NSE, HOXC9, GAP43). 9-cis-UAB30 has no adverse effects on the central nervous system and cardiovascular system at the tested dose. 9-cis-UAB30 can be used for the study of neuroblastoma, cutaneous T-cell lymphomas, and breast cancer .
Assay Types