2095489-35-1
Chemical Structure
BRF110
- CAS No.: 2095489-35-1
- Formula:C22H18F3N3O2
- Molecular Weight:413.39
IUPAC Name: 4-((5-allyl-2-phenyl-6-(trifluoromethyl)pyrimidin-4-yl)(methyl)amino)benzoic acid
InChIKey: WFLMIJKKTIOYSO-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(N(C)C2=NC(C3=CC=CC=C3)=NC(C(F)(F)F)=C2CC=C)C=C1
Biological Activity: BRF110 is an orally active, blood-brain barrier-penetrant Nurr1-RXRα heterodimer activator with an EC50 of 0.9 μM in human systems. BRF110 increases the mRNA level of BDNF, upregulates the transcription of TH, AADC and GCH1 to elevate striatal dopamine levels. BRF110 exhibits neuroprotective activity against MPP+-induced cytotoxicity. BRF110 prevents dopaminergic neuron death, protects nerve cells from toxic damage, and improves motor coordination in mouse models. BRF110 can be used in research related to Parkinson's disease[1][2].
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BRF110 | BRF110 is an orally active, blood-brain barrier-penetrant Nurr1-RXRα heterodimer activator with an EC50 of 0.9 μM in human systems. BRF110 increases the mRNA level of BDNF, upregulates the transcription of TH, AADC and GCH1 to elevate striatal dopamine levels. BRF110 exhibits neuroprotective activity against MPP+-induced cytotoxicity. BRF110 prevents dopaminergic neuron death, protects nerve cells from toxic damage, and improves motor coordination in mouse models. BRF110 can be used in research related to Parkinson's disease. | |||||||||||||||||||||
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- [1]. Asvos X, et al. BRF110, an Orally Active Nurr1-RXRα-Selective Rexinoid, Enhances BDNF Expression without Elevating Triglycerides. Journal of medicinal chemistry. 2025 Feb 27;68(4):4763-4786. [Content Brief]
- [2]. Spathis AD, et al. Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2017 Apr 11;114(15):3999-4004.
Keywords
