2095489-35-1
Chemical Structure
BRF110
- CAS No.: 2095489-35-1
- Formula:C22H18F3N3O2
- Molecular Weight:413.39
IUPAC Name: 4-((5-allyl-2-phenyl-6-(trifluoromethyl)pyrimidin-4-yl)(methyl)amino)benzoic acid
InChIKey: WFLMIJKKTIOYSO-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(N(C)C2=NC(C3=CC=CC=C3)=NC(C(F)(F)F)=C2CC=C)C=C1
Biological Activity: BRF110 is the selective, orally active rexinoid for Nurr1-RXRα, that selectively activates the Nurr1-RXRα heterodimer with an EC50 of 0.9 μM in SH-SY5Y. BRF110 upregulates the expression of BDNF, exhibits neuroprotective activity against MPP+ induced toxicity. BRF110 can cross blood-brain barrier[1].
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BRF110 | BRF110 is the selective, orally active rexinoid for Nurr1-RXRα, that selectively activates the Nurr1-RXRα heterodimer with an EC50 of 0.9 μM in SH-SY5Y. BRF110 upregulates the expression of BDNF, exhibits neuroprotective activity against MPP+ induced toxicity. BRF110 can cross blood-brain barrier. | |||||||||||||||||||||
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Keywords
