Chrnb4 - cholinergic receptor nicotinic beta 4 subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25103

Summary

Enables acetylcholine binding activity and heterocyclic compound binding activity. Predicted to be involved in several processes, including chemical synaptic transmission; positive regulation of transmission of nerve impulse; and regulation of membrane potential. Predicted to act upstream of or within several processes, including behavioral response to nicotine; smooth muscle contraction; and synaptic transmission involved in micturition. Located in neuron projection and plasma membrane. Part of acetylcholine-gated channel complex. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrnb4 Products (1)

mRNA Protein Name
NM_052806.3 NP_434693.1 neuronal acetylcholine receptor subunit beta-4 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine binding IDA
IDA: Inferred from direct assay
9030613 RGD
enables heterocyclic compound binding IDA
IDA: Inferred from direct assay
15016836 RGD
contributes to heterocyclic compound binding IPI
IPI: Inferred from physical interaction
16129735 RGD
enables heterocyclic compound binding IPI
IPI: Inferred from physical interaction
15016836 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20566638 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
20796176 RGD
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
9030613 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
19474315 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16129735 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit beta-4

  • Acetylcholine receptor beta 4

  • N-alpha 2

  • cholinergic receptor, nicotinic beta 4

  • cholinergic receptor, nicotinic, beta 4 (neuronal)

  • cholinergic receptor, nicotinic, beta polypeptide 4

  • neuronal acetylcholine receptor non-alpha-2 chain

  • nicotinic acetylc

Chrnb4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Chrnb4 P12392 Chrna4 Rattus norvegicus P09483
Anti Bait CoIP
20566638
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02677 CHRNB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrnb4 NCBI NCBI:1143