Chrna4 - cholinergic receptor nicotinic alpha 4 subunit Gene

Also Known as NARAC

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25590

Summary

Enables acetylcholine binding activity; acetylcholine-gated cation-selective channel activity; and quaternary ammonium group binding activity. Contributes to heterocyclic compound binding activity. Involved in cholinergic synaptic transmission; regulation of acetylcholine-gated cation channel activity; and response to acetylcholine. Located in dendrite; membrane; and neuronal cell body. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna4 Products (1)

mRNA	Protein	Name
NM_024354.2	NP_077330.2	neuronal acetylcholine receptor subunit alpha-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acetylcholine binding	IDA IDA: Inferred from direct assay	9030613	RGD
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA IDA: Inferred from direct assay	12202488	RGD
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP IMP: Inferred from mutant phenotype	11259617	RGD
contributes to heterocyclic compound binding	IDA IDA: Inferred from direct assay	22550286	RGD
enables heterocyclic compound binding	IDA IDA: Inferred from direct assay	15016836	RGD
contributes to heterocyclic compound binding	IPI IPI: Inferred from physical interaction	16129735	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12202488	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	20796176	RGD
enables quaternary ammonium group binding	IDA IDA: Inferred from direct assay	15016836	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP EXP: Inferred from Experiment	15044058	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	15044058	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of acetylcholine-gated cation channel activity	IMP IMP: Inferred from mutant phenotype	11904236	RGD
involved in response to acetylcholine	IDA IDA: Inferred from direct assay	15016836	RGD
involved in synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	15026122	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of acetylcholine-gated channel complex	IDA IDA: Inferred from direct assay	9030613	RGD
is active in cholinergic synapse	EXP EXP: Inferred from Experiment	15044058	RGD
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	10414976	RGD
located in dendrite	IDA IDA: Inferred from direct assay	11297818	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11297818	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	10414976	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	24607281	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16129735	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neuronal acetylcholine receptor subunit alpha-4	Neuronal nicotinic acetylcholine receptor alpha 4 subunit cholinergic receptor, nicotinic, alpha 4 (neuronal) cholinergic receptor, nicotinic, alpha polypeptide 4

Chrna4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Chrna4	P09483	Chrna5	Rattus norvegicus	P20420	Density Sedimentation	20566638
Intra	Chrna4	P09483	Chrna5	Rattus norvegicus	P20420	BN-PAGE	20566638
Intra	Chrna4	P09483	Chrnb2	Rattus norvegicus	P12390	Density Sedimentation	20566638
Intra	Chrna4	P09483	Chrnb2	Rattus norvegicus	P12390	BN-PAGE	20566638
Intra	Chrna4	P09483	Chrnb4	Rattus norvegicus	P12392	BN-PAGE	20566638

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02669	CHRNA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrna4	NCBI	NCBI:1137