Chrnb2 - cholinergic receptor nicotinic beta 2 subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 54239

Summary

Enables acetylcholine binding activity; acetylcholine-gated cation-selective channel activity; and quaternary ammonium group binding activity. Contributes to heterocyclic compound binding activity. Involved in acetylcholine receptor signaling pathway; cholinergic synaptic transmission; and response to nicotine. Located in plasma membrane raft. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrnb2 Products (1)

mRNA	Protein	Name
NM_019297.2	NP_062170.1	neuronal acetylcholine receptor subunit beta-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acetylcholine binding	IDA IDA: Inferred from direct assay	9030613	RGD
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA IDA: Inferred from direct assay	11956333	RGD
enables acetylcholine-gated monoatomic cation-selective channel activity	IGI IGI: Inferred from genetic interaction	21540349	RGD
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP IMP: Inferred from mutant phenotype	11259617	RGD
contributes to heterocyclic compound binding	IDA IDA: Inferred from direct assay	22550286	RGD
enables heterocyclic compound binding	IDA IDA: Inferred from direct assay	15016836	RGD
contributes to heterocyclic compound binding	IPI IPI: Inferred from physical interaction	16129735	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20566638	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	20796176	RGD
enables quaternary ammonium group binding	IDA IDA: Inferred from direct assay	15016836	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP EXP: Inferred from Experiment	15044058	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	15044058	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in acetylcholine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	21540349	RGD
involved in response to acetylcholine	IDA IDA: Inferred from direct assay	15016836	RGD
involved in response to acetylcholine	IGI IGI: Inferred from genetic interaction	21540349	RGD
involved in response to nicotine	IMP IMP: Inferred from mutant phenotype	14764595	RGD
involved in synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	12754307	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of acetylcholine-gated channel complex	IDA IDA: Inferred from direct assay	9030613	RGD
part of acetylcholine-gated channel complex	IGI IGI: Inferred from genetic interaction	21540349	RGD
is active in cholinergic synapse	EXP EXP: Inferred from Experiment	15044058	RGD
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	3380297	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	19474315	RGD
located in plasma membrane raft	IGI IGI: Inferred from genetic interaction	21540349	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	3380297	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	24607281	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16129735	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neuronal acetylcholine receptor subunit beta-2	N-alpha 1 cholinergic receptor nicotinic beta polypeptide 2 cholinergic receptor, nicotinic beta 2 cholinergic receptor, nicotinic, beta 2 (neuronal) cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) cholinergic receptor, nicotinic, beta

Chrnb2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Chrnb2	P12390	Chrna4	Rattus norvegicus	P09483	Anti Bait CoIP	20566638

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02675	CHRNB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrnb2	NCBI	NCBI:1141