country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

MT2A - metallothionein 2A Gene

Also Known as MT2; MT-2; MT-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4502

About MT2A

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,608,584-56,609,497 (from NCBI)

This gene has 5 transcripts (splice variants), 156 orthologues and 11 paralogues. Broad expression in adrenal (RPKM 718.8), liver (RPKM 608.8) and 20 other tissues.

Summary

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and Autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of Cancer. [provided by RefSeq, Sep 2017]

MT2A Products (1)

mRNA	Protein	Name
NM_005953.5	NP_005944.1	metallothionein-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12646258	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to erythropoietin	IEP IEP: Inferred from expression pattern	11168427	GOA
involved in cellular response to interleukin-3	IEP IEP: Inferred from expression pattern	11168427	GOA
involved in cellular response to zinc ion	IEP IEP: Inferred from expression pattern	11168427	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT2A Protein Structure

Metallothio

0
61 a.a.

Protein Preferred Names	Protein Names
metallothionein-2	metallothionein-II

MT2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MT2A	P02795	PRKD1	Homo sapiens	Q15139	Y2H	14550308
Intra	MT2A	P02795	PRKD1	Homo sapiens	Q15139	Anti Bait CoIP	14550308
Intra	MT2A	P02795	SPINK7	Homo sapiens	P58062	Y2H	12646258
Intra	MT2A	P02795	SPINK7	Homo sapiens	P58062	Anti Tag CoIP	12646258
Intra	MT2A	P02795	APOE	Homo sapiens	P02649	Y2H Array	32814053
Intra	MT2A	P02795	APOE	Homo sapiens	P02649	Validated Y2H	32814053
Intra	MT2A	P02795	APOE	Homo sapiens	P02649	Y2H Pooling	32814053
Intra	MT2A	P02795	COL26A1	Homo sapiens	Q96A83-2	Validated Y2H	32814053
Intra	MT2A	P02795	COL26A1	Homo sapiens	Q96A83-2	Y2H Array	32814053
Intra	MT2A	P02795	COL26A1	Homo sapiens	Q96A83-2	Y2H Pooling	32814053
Intra	MT2A	P02795	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	MT2A	P02795	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	MT2A	P02795	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	MT2A	P02795	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	MT2A	P02795	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	MT2A	P02795	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	MT2A	P02795	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	MT2A	P02795	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	MT2A	P02795	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	MT2A	P02795	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
Intra	MT2A	P02795	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	MT2A	P02795	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
Intra	MT2A	P02795	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	MT2A	P02795	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	MT2A	P02795	SNCA	Homo sapiens	P37840	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Scrapie
Osteogenesis Imperfecta, Type X	Osteogenesis Imperfecta Type 10 OI10 Osteogenesis Imperfecta Type X Oi, Type X Osteogenesis Imperfecta 10 Oi Type X Oi-X
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Menkes Disease	Copper Transport Disease Menkes Syndrome MNK Kinky Hair Disease Steely Hair Disease Menkes Kinky-Hair Syndrome Mk Steely Hair Syndrome Menkea Syndrome Md Menkes Kinky Hair Syndrome Hypocupremia, Congenital Kinky Hair Syndrome X-Linked Copper Deficiency Menkes Kinky Hair Disease
Deficiency Anemia	Anemia Deficiency Anemias Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08743	MT2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-168969	AA-BR-157		96.47%	Unkown
HY-168970	MT2A ligand 1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MT2A	MGD	MGI:97172
Rattus norvegicus	MT2A	RGD	RGD:1592345
Others	MT2A	NCBI