Wasl - WASP like actin nucleation promoting factor Gene

Also Known as N-WASP; 2900021I12Rik; 3110031I02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 73178

Summary

Predicted to enable cytoskeletal protein binding activity and identical protein binding activity. Involved in dendritic spine morphogenesis. Acts upstream of or within several processes, including actin Cytoskeleton organization; response to bacterium; and spindle localization. Located in actin cap and lamellipodium. Is expressed in brain; genitourinary system; liver; and spleen. Used to study atopic dermatitis. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Apr 2022]

Wasl Products (2)

mRNA Protein Name
NM_001167745.1 NP_001161217.1 actin nucleation-promoting factor WASL isoform 2
NM_028459.2 NP_082735.2 actin nucleation-promoting factor WASL isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11082044 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21874009 MGI
NOT acts upstream of or within cell projection assembly IMP
IMP: Inferred from mutant phenotype
11559594 MGI
involved in dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
25851601 MGI
acts upstream of or within protein-containing complex localization IMP
IMP: Inferred from mutant phenotype
21874009 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
25851601 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
25851601 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
22966049 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
11559594 MGI
acts upstream of or within spindle localization IMP
IMP: Inferred from mutant phenotype
21874009 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cap IDA
IDA: Inferred from direct assay
21874009 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25851601 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25851601 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
15148305 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin nucleation-promoting factor WASL

neural Wiskott-Aldrich syndrome protein

  • Wiskott-Aldrich syndrome-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15747 WASL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wasl NCBI NCBI:8976