IQCE - IQ motif containing E Gene

Also Known as PAPA7; 1700028P05Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23288

About IQCE

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:2,558,979-2,614,728 (from NCBI)

This gene has 17 transcripts (splice variants), 69 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in testis (RPKM 11.3), brain (RPKM 6.8) and 24 other tissues.

Summary

Involved in limb morphogenesis. Predicted to be extrinsic component of membrane. Predicted to be part of plasma membrane protein complex. [provided by Alliance of Genome Resources, Apr 2022]

IQCE Products (6)

mRNA	Protein	Name
NM_001287499.2	NP_001274428.1	IQ domain-containing protein E isoform 3
NM_001287500.2	NP_001274429.1	IQ domain-containing protein E isoform 4
NM_001287501.2	NP_001274430.1	IQ domain-containing protein E isoform 5
NM_001287502.2	NP_001274431.1	IQ domain-containing protein E isoform 6
NM_001410865.1	NP_001397794.1	IQ domain-containing protein E isoform 7
NM_152558.5	NP_689771.3	IQ domain-containing protein E isoform 1

IQCE Protein Structure

IQ

0
200
400
600
695 a.a.

Protein Preferred Names	Protein Names
IQ domain-containing protein E

IQCE Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IQCE	Q6IPM2	HEL-S-72	Homo sapiens	B4DJ51	Y2H Array	25416956
Intra	IQCE	Q6IPM2	HEL-S-72	Homo sapiens	B4DJ51	Validated Y2H	25416956
Intra	IQCE	Q6IPM2	q9brl5_human	Homo sapiens	Q9BRL5	Validated Y2H	25416956
Intra	IQCE	Q6IPM2	q9brl5_human	Homo sapiens	Q9BRL5	Y2H Prey Pooling	25416956
Intra	IQCE	Q6IPM2	q9brl5_human	Homo sapiens	Q9BRL5	Y2H Array	25416956
Intra	IQCE	Q6IPM2	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	IQCE	Q6IPM2	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	IQCE	Q6IPM2	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	IQCE	Q6IPM2	PSMA3	Homo sapiens	P25788	Y2H Prey Pooling	25416956
Intra	IQCE	Q6IPM2	PSMA3	Homo sapiens	P25788	Y2H Array	24722188
Intra	IQCE	Q6IPM2	TTC23L	Homo sapiens	Q6PF05	Y2H Array	24722188

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Polydactyly, Postaxial, Type A7	PAPA7 Polydactyly, Postaxial, A7
Polydactyly, Postaxial, Type A1	Postaxial Polydactyly Type A Polydactyly, Postaxial Postaxial Polydactyly PAPA1 Postaxial Polydactyly, Type A Papa Polydactyly, Postaxial, Types A1 And B Postaxial Polydactyly Type B Polydactyly Postaxial Polydactyly, Postaxial A1 Polydactyly, Postaxial B PAPB Postaxial Polydactyly, Type A1/B Polydactyly, Postaxial, Type A Pyogenic Arthritis, Pyoderma Gangrenosum And Acne Postaxial Polydactyly, Type B
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Retinal Degeneration	Degeneration Of Retina
Brachydactyly
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits
Weyers Acrofacial Dysostosis	Curry-Hall Syndrome Weyers Acrodental Dysostosis WAD Acrodental Dysostosis Of Weyers Acrofacial Dysostosis, Weyers Type Acrofacial Dysostosis Of Weyers Curry Hall Syndrome
Short-Rib Thoracic Dysplasia 14 With Polydactyly	SRTD14
Basal Cell Carcinoma, Infundibulocystic	Basal Cell Carcinoma With Follicular Differentiation Infundibulocystic Basal Cell Carcinoma Skin Infundibulocystic Basal Cell Carcinoma
Skin Tag	Fibroepithelial Polyp Fibroepithelial Polyp Of Skin Soft Fibroma Skin Tags Cutaneous Tag Gardner Fibroma Acrochordon Fibroma Molle
Laurin-Sandrow Syndrome	Sandrow Syndrome Tetramelic Mirror-Image Polydactyly Mirror-Image Polydactyly Mirror Hands And Feet With Nasal Defects Tmip LSS Mip Mirror Hands And Feets-Nasal Defects Syndrome Fibula And Ulna, Duplication Of, With Absence Of Tibia And Radius Miccor Hands And Feet With Nasal Defects Mipduplication Of Fibuland Ulna With Absence Of Tibia And Radius Fibula Ulna Duplication Tibia Radius Absence Laurin Sandrow Syndrome Duplication Of Fibula And Ulna With Absence Of Tibia And Radius Segmental Laurin-Sandrow Syndrome Laurin-Sandrow Syndrome, Segmental
Greig Cephalopolysyndactyly Syndrome	GCPS Polysyndactyly With Peculiar Skull Shape Polysyndactyly With Peculiars Skull Shape Greig Syndrome Cephalopolysyndactyly Syndrome Greig Cephalo-Poly-Syndactyly Syndrome Cephalopolysyndactyly, Greig Syndrome Aarskog Syndrome
Acrofacial Dysostosis
Ellis-Van Creveld Syndrome	Chondroectodermal Dysplasia Mesoectodermal Dysplasia EVC Ellis Van Creveld Syndrome Mesodermic Dysplasia Ellis-Van Creveld Dysplasia
Pallister-Hall Syndrome	PHS Hypothalamic Hamartomas Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly Hypothalamic Hamartoblastoma Syndrome Hamartoma Of The Hypothalamus Pallister Hall Syndrome Hall-Pallister Syndrome Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly Hamartoma, Hypothalamic
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06878	IQCE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IQCE	MGD	MGI:1921489
Canis familiaris	IQCE	VGNC	VGNC:42076
Macaca mulatta	IQCE	VGNC	VGNC:73678
Rattus norvegicus	IQCE	RGD	RGD:1311349
Felis catus	IQCE	VGNC	VGNC:62962
Bos taurus	IQCE	VGNC	VGNC:30253
Others	IQCE	NCBI