Plcb3 - phospholipase C beta 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29322

Summary

Enables phosphatidylinositol Phospholipase C activity. Involved in several processes, including inositol trisphosphate metabolic process; phosphatidylinositol catabolic process; and phosphatidylinositol-mediated signaling. Located in cytosol and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (Phospholipase C beta 3). [provided by Alliance of Genome Resources, Apr 2022]

Plcb3 Products (1)

mRNA Protein Name
NM_033350.1 NP_203501.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol phospholipase C activity IDA
IDA: Inferred from direct assay
8454637 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15632121 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16314422 RGD
involved in inositol trisphosphate metabolic process IDA
IDA: Inferred from direct assay
8387502 RGD
involved in phosphatidylinositol catabolic process IDA
IDA: Inferred from direct assay
8387502 RGD
involved in post-Golgi vesicle-mediated transport IDA
IDA: Inferred from direct assay
17492941 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
8454637 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15362504 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

  • PLC-beta-3

  • phosphoinositide phospholipase C-beta-3

  • phospholipase C, beta 3 (phosphatidylinositol-specific)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10654 PLCB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plcb3 NCBI NCBI:5331