1356734-45-6
Chemical Structure
Lck-IN-5
- No. CAS: 1356734-45-6
- Formula:C25H24FN5O2
- Molecular Weight:445.49
InChIKey: OQBLNLIECCWNLO-UHFFFAOYSA-N
SMILES: CC1=CC(C2=NOC(CN3CCC4(CC4C5=NN=C(O5)C6=CC(F)=CC=C6)CC3)=N2)=CC=C1
Biological Activity: Lck-IN-5 (example C10) is a potent and selective lymphocyte-specific protein tyrosine kinase (LCK) inhibitor. Lck-IN-5 selectively disrupts the interaction between the SH3 domain of LCK and the RK motif of CD3ε, thereby impairing LCK recruitment to the TCR. Lck-IN-5 modulates the activity of CD3ε-containing CAR and TRuC T cells, attenuating cytokine production and promoting a central-memory-like phenotype associated with enhanced persistence. Lck-IN-5 can be used for autoimmune diseases and graft-versus-host disease research[1].
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Lck-IN-5 | 98.09% | Lck-IN-5 (example C10) is a potent and selective lymphocyte-specific protein tyrosine kinase (LCK) inhibitor. Lck-IN-5 selectively disrupts the interaction between the SH3 domain of LCK and the RK motif of CD3ε, thereby impairing LCK recruitment to the TCR. Lck-IN-5 modulates the activity of CD3ε-containing CAR and TRuC T cells, attenuating cytokine production and promoting a central-memory-like phenotype associated with enhanced persistence. Lck-IN-5 can be used for autoimmune diseases and graft-versus-host disease research. | ||||||||||||||||||||
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Keywords
