142326-59-8
142326-59-8
Chemical Structure
L-701324
- No. CAS: 142326-59-8
- Formula:C21H14ClNO3
- Molecular Weight:363.79
IUPAC Name: 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2(1H)-one
InChIKey: FLVRDMUHUXVRET-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=CC(Cl)=C2)C(O)=C1C3=CC=CC(OC4=CC=CC=C4)=C3
Biological Activity: L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity[1][2][3].
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L-701324 | 99.85% | L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity. | ||||||||||||||||||||
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References
- [1]. Liu L, et, al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization. Behav Brain Res. 2021 Feb 5;399:113038. [Content Brief]
- [2]. Kotlinska J, et, al. A characterization of anxiolytic-like actions induced by the novel NMDA/glycine site antagonist, L-701,324. Psychopharmacology (Berl). 1998 Jan;135(2):175-81. [Content Brief]
- [3]. Hutson PH, et, al. L-701,324, a glycine/NMDA receptor antagonist, blocks the increase of cortical dopamine metabolism by stress and DMCM. Eur J Pharmacol. 1997 May 20;326(2-3):127-32. [Content Brief]
Keywords
