2028316-07-4
Chemical Structure
CDy11
- No. CAS: 2028316-07-4
- Formula:C27H23BF3N3O2
- Molecular Weight:489.30
InChIKey: AAUPNIKKSLKADN-XYOKQWHBSA-N
SMILES: CC(C=C1/C=C/C2=C(F)C=C(OC)C=C2)=C(N1[B-]3(F)F)C(C4=CC=C(NC(C)=O)C=C4)=C5[N+]3=CC=C5
Biological Activity: CDy11 is a fluorescent probe and amyloid-binding dye (λex=590 nm; λem=612 nm), with a Ka of 29 μM for Pseudomonas aeruginosa Fap. CDy11 specifically recognizes amyloid fibrils in bacterial biofilms and exhibits significantly enhanced fluorescence upon binding to the target. CDy11 shows no staining effect on amyloid-deficient mutant strains, planktonic cells or protein monomers. CDy11 supports in vivo imaging of Pseudomonas aeruginosa biofilms in mouse implant and corneal infection models. CDy11 is widely used in studies of Staphylococcus aureus biofilm infections, dental caries, and Pseudomonas aeruginosa-associated implant and corneal infections[1][2][3].
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CDy11 | CDy11 is a fluorescent probe and amyloid-binding dye (λex=590 nm; λem=612 nm), with a Ka of 29 μM for Pseudomonas aeruginosa Fap. CDy11 specifically recognizes amyloid fibrils in bacterial biofilms and exhibits significantly enhanced fluorescence upon binding to the target. CDy11 shows no staining effect on amyloid-deficient mutant strains, planktonic cells or protein monomers. CDy11 supports in vivo imaging of Pseudomonas aeruginosa biofilms in mouse implant and corneal infection models. CDy11 is widely used in studies of Staphylococcus aureus biofilm infections, dental caries, and Pseudomonas aeruginosa-associated implant and corneal infections. | |||||||||||||||||||||
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- [1]. Sauvat L, et al. Biofilm-coated microbeads and the mouse ear skin: An innovative model for analysing anti-biofilm immune response in vivo. PLoS One. 2020;15(12):e0243500. Published 2020 Dec 4. [Content Brief]
- [2]. Kim JY, et al. Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11. J Am Chem Soc. 2016;138(1):402-407. [Content Brief]
- [3]. Barran-Berdon AL, et al. Enhanced purification coupled with biophysical analyses shows cross-β structure as a core building block for Streptococcus mutans functional amyloids. Sci Rep. 2020;10(1):5138. Published 2020 Mar 20. [Content Brief]
Keywords
