SLC26A8 - solute carrier family 26 member 8 Gene

Also Known as TAT1; SPGF3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116369

About SLC26A8

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,943,516-36,024,641 (from NCBI)

This gene has 8 transcripts (splice variants), 111 orthologues, 9 paralogues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 27.9).

Summary

This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]

SLC26A8 Products (3)

mRNA	Protein	Name
NM_001193476.2	NP_001180405.1	testis anion transporter 1 isoform a
NM_052961.4	NP_443193.1	testis anion transporter 1 isoform a
NM_138718.3	NP_619732.2	testis anion transporter 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables chloride channel activity	IDA IDA: Inferred from direct assay	11834742	GOA
enables oxalate transmembrane transporter activity	IDA IDA: Inferred from direct assay	11834742	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11278976	GOA
enables sulfate transmembrane transporter activity	IDA IDA: Inferred from direct assay	11834742	GOA
enables sulfate:chloride antiporter activity	IDA IDA: Inferred from direct assay	11278976	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in chloride transport	IDA IDA: Inferred from direct assay	11278976	GOA
involved in oxalate transport	IDA IDA: Inferred from direct assay	11834742	GOA
involved in sulfate transmembrane transport	IDA IDA: Inferred from direct assay	11278976	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11278976	GOA
located in sperm annulus	IDA IDA: Inferred from direct assay	17517695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC26A8 Protein Structure

Sulfate_transp

STAS

0
200
400
600
800
970 a.a.

Protein Preferred Names	Protein Names
testis anion transporter 1	anion transporter/exchanger-8

SLC26A8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	SLC26A8	Q96RN1	RACGAP1	Homo sapiens	Q9H0H5	Y2H	11278976

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spermatogenic Failure 3	SPGF3 Azoospermia, Nonobstructive
Non-Syndromic Male Infertility Due To Sperm Motility Disorder	Non-Syndromic Male Infertility Due Asthenozoospermia
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Diastrophic Dysplasia	Diastrophic Dwarfism DTD Dd Diastrophic Dysplasia, Broad Bone-Platyspondylic Variant Dysplasia, Diastrophic Diastrophic Dysplasia Variant
Infertility
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Atelosteogenesis	Atelosteogenesis, Type 1
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS13142	SLC26A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC26A8	RGD	RGD:1308898
Mus musculus	SLC26A8	MGD	MGI:2385046
Bos taurus	SLC26A8	VGNC	VGNC:34783
Macaca mulatta	SLC26A8	VGNC	VGNC:77479
Felis catus	SLC26A8	VGNC	VGNC:65286
Canis familiaris	SLC26A8	VGNC	VGNC:46327
Others	SLC26A8	NCBI