Axin1 - axin 1 Gene

Also Known as Fu; Kb; Ki; Axin; fused; kinky; knobbly

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12005

Summary

Enables several functions, including SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in positive regulation of JNK cascade; positive regulation of protein modification process; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule metabolic process; and regulation of protein metabolic process. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and microtubule Cytoskeleton. Part of Wnt signalosome and beta-catenin destruction complex. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Apr 2022]

Axin1 Products (5)

mRNA Protein Name
NM_001159598.2 NP_001153070.2 axin-1 isoform 1
NM_001394381.1 NP_001381310.1 axin-1 isoform 2
NM_001394382.1 NP_001381311.1 axin-1 isoform 1
NM_001394389.1 NP_001381318.1 axin-1 isoform 1
NM_009733.3 NP_033863.3 axin-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables I-SMAD binding IDA
IDA: Inferred from direct assay
16601693 MGI
enables I-SMAD binding IPI
IPI: Inferred from physical interaction
16601693 MGI
enables R-SMAD binding IPI
IPI: Inferred from physical interaction
16601693 MGI
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
10318824 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
9920888 MGI
enables p53 binding IPI
IPI: Inferred from physical interaction
15526030 MGI
enables protein binding IDA
IDA: Inferred from direct assay
10318824 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9920888 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15579909 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
17681137 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
10318824 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16601693 MGI
enables ubiquitin-like ligase-substrate adaptor activity IMP
IMP: Inferred from mutant phenotype
16601693 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
11113207 MGI
acts upstream of or within Wnt signaling pathway IPI
IPI: Inferred from physical interaction
11113207 MGI
acts upstream of or within axial mesoderm development IMP
IMP: Inferred from mutant phenotype
9230313 MGI
acts upstream of or within axial mesoderm formation IMP
IMP: Inferred from mutant phenotype
9230313 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
10937998 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19075000 MGI
acts upstream of or within cytoplasmic microtubule organization IGI
IGI: Inferred from genetic interaction
14734535 MGI
acts upstream of or within dorsal/ventral axis specification IDA
IDA: Inferred from direct assay
10330403 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
18316368 MGI
acts upstream of or within epigenetic programming in the zygotic pronuclei IMP
IMP: Inferred from mutant phenotype
12601169 MGI
acts upstream of or within head development IMP
IMP: Inferred from mutant phenotype
21344612 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
19204372 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
19204372 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
9230313 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
15579909 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
10937998 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
18076571 MGI
acts upstream of or within negative regulation of protein metabolic process IDA
IDA: Inferred from direct assay
10330403 MGI
acts upstream of or within negative regulation of transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
10318824 MGI
acts upstream of or within nucleocytoplasmic transport IDA
IDA: Inferred from direct assay
14981260 MGI
acts upstream of or within positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
18316368 MGI
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
17681137 MGI
acts upstream of or within positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
12878610 MGI
acts upstream of or within positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
12878610 MGI
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
11955436 MGI
involved in positive regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
11955436 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16601693 MGI
involved in positive regulation of protein kinase activity IDA
IDA: Inferred from direct assay
15526030 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
10330403 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
16601693 MGI
acts upstream of or within positive regulation of protein ubiquitination IGI
IGI: Inferred from genetic interaction
16601693 MGI
acts upstream of or within positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
16601693 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
16601693 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
16601693 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16601693 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16601693 MGI
acts upstream of or within positive regulation of ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16601693 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
12601169 MGI
acts upstream of or within protein catabolic process IDA
IDA: Inferred from direct assay
12717450 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: Inferred from direct assay
16601693 MGI
acts upstream of or within regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
14981260 MGI
acts upstream of or within regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
14734535 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
21003499 MGI
Cellular Component GO Annotation Evidence Referencias Source
part of Wnt signalosome IDA
IDA: Inferred from direct assay
22899650 MGI
part of beta-catenin destruction complex IDA
IDA: Inferred from direct assay
10318824 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
10330403 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11113207 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
11113207 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
14734535 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10330403 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
16601693 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

axin-1

  • axis inhibition protein 1

  • protein Fused

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-147245 Basroparib Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-173349 TDI-012804 Inhibitor / Unkown
HY-RS22402 Axin1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107528 FRATtide Inhibitor / Unkown
HY-141543 YW2065 Inhibitor 99.91% Unkown
HY-RS01291 AXIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Axin1 NCBI NCBI:8312