Nr2e3 - nuclear receptor subfamily 2, group E, member 3 Gene

Also Known as PNR; RNR; rd7; A930035N01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23958

Summary

Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including eye development; negative regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in 1st branchial arch maxillary component; early conceptus; eye; and oocyte. Used to study enhanced S-cone syndrome. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Orthologous to human NR2E3 (nuclear receptor subfamily 2 group E member 3). [provided by Alliance of Genome Resources, Apr 2022]

Nr2e3 Products (1)

mRNA Protein Name
NM_013708.4 NP_038736.1 photoreceptor-specific nuclear receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15689355 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15689355 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12407160 MGI
acts upstream of or within eye photoreceptor cell development IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12407160 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15689355 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
15689355 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15689355 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
12407160 MGI
Cellular Component GO Annotation Evidence Referencias Source
located in nucleus IDA
IDA: Inferred from direct assay
15689355 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15689355 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

photoreceptor-specific nuclear receptor

  • retina-specific nuclear receptor

  • retinal degeneration 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-161115 NR2E3 agonist 1 Agonist 99.48% Unkown
HY-RS09540 NR2E3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr2e3 NCBI NCBI:10002