AMDHD2 - amidohydrolase domain containing 2 Gene

Also Known as CGI-14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51005

About AMDHD2

This gene has 19 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in spleen (RPKM 8.7), kidney (RPKM 8.5) and 25 other tissues.

Summary

Enables N-acetylglucosamine-6-phosphate deacetylase activity. Predicted to be involved in N-acetylglucosamine catabolic process. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

AMDHD2 Products (4)

mRNA Protein Name
NM_001145815.2 NP_001139287.1 N-acetylglucosamine-6-phosphate deacetylase isoform 2
NM_001330449.2 NP_001317378.1 N-acetylglucosamine-6-phosphate deacetylase isoform 3
NM_001410943.1 NP_001397872.1 N-acetylglucosamine-6-phosphate deacetylase isoform 4
NM_015944.4 NP_057028.2 N-acetylglucosamine-6-phosphate deacetylase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Referencias Source
NOT enables N-acetylgalactosamine-6-phosphate deacetylase activity IDA
IDA: Inferred from direct assay
35229715 GOA
enables N-acetylglucosamine-6-phosphate deacetylase activity IDA
IDA: Inferred from direct assay
22692205 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in negative regulation of UDP-N-acetylglucosamine biosynthetic process IDA
IDA: Inferred from direct assay
35229715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMDHD2 Protein Structure

(57 - 383)

  • 0
  • 100
  • 200
  • 300
  • 409 a.a.
Protein Preferred Names Protein Names

N-acetylglucosamine-6-phosphate deacetylase

  • amidohydrolase domain-containing protein 2

AMDHD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
AMDHD2 Q9Y303 GNPDA2 Homo sapiens Q8TDQ7
Validated Y2H
25416956
Intra
AMDHD2 Q9Y303 GNPDA2 Homo sapiens Q8TDQ7
Y2H Prey Pooling
25416956
Intra
AMDHD2 Q9Y303 GNPDA2 Homo sapiens Q8TDQ7
Y2H Array
29892012
Intra
AMDHD2 Q9Y303 TRIP13 Homo sapiens Q15645
Y2H Array
25416956
Intra
AMDHD2 Q9Y303 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS00646 AMDHD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AMDHD2 RGD RGD:1304601
Mus musculus AMDHD2 MGD MGI:2443978
Others AMDHD2 NCBI