TRPV5 - transient receptor potential cation channel subfamily V member 5 Gene

Also Known as CAT2; ECAC1; OTRPC3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56302

About TRPV5

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:142,908,101-142,933,746 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 101 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]

TRPV5 Products (1)

mRNA	Protein	Name
NM_019841.7	NP_062815.3	transient receptor potential cation channel subfamily V member 5

TRPV5 Protein Structure

Ank_2

Ion_trans

0
200
400
600
729 a.a.

Protein Preferred Names	Protein Names
transient receptor potential cation channel subfamily V member 5	calcium transport protein 2

TRPV5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	TRPV5	Q9NQA5	CALB1	Homo sapiens	P05937	Pull Down	16763551

Cross: Cross-species interaction Intra: Intraspecies interaction

TRPV5 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P82539	TrpV5 Antibody (YA2284)	WB, IP	Human, Mouse, Rat
HY-P82539A	TrpV5 Antibody (YA2284)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Urolithiasis
Pseudohypoaldosteronism
Scapuloperoneal Spinal Muscular Atrophy	SPSMA Amyotrophy, Neurogenic Scapuloperoneal, New England Type Neurogenic Scapuloperoneal Amyotrophy, New England Type Scapuloperoneal Neuronopathy Spinal Muscular Atrophy, Scapuloperoneal Amyotrophy Neurogenic Scapuloperoneal New England Type Muscular Atrophy, Spinal Scapuloperoneal Form Of Spinal Muscular Atrophy
Hypervitaminosis D	Vitamin D Hyperalimentation
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques	Olmsted Syndrome Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques Palmoplantar And Periorificial Keratoderma Olms
Metatropic Dysplasia	Metatropic Dwarfism MTD Metatropic Dysplasia Type 1 Metatropic Dysplasia, Nonlethal Dominant
Skin Atrophy	Atrophic Condition Of Skin Atrophoderma Atrophy - Skin
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Mucolipidosis Iv	Mucolipidosis Type Iv ML4 Sialolipidosis Mucolipidosis Type 4 Ganglioside Sialidase Deficiency Mliv Ml Iv Berman Syndrome Ganglioside Neuraminidase Deficiency Ml 4 Mucolipidosis 4 Type Iv Mucolipidosis Gangliosidoses
Phosphorus Metabolism Disease	Phosphorus Metabolism Disorders Disorder Of Phosphorus Metabolism Phosphorus Disorder Phosphorus Metabolism Disorder
Schnyder Corneal Dystrophy	Schnyder Crystalline Corneal Dystrophy SCCD Corneal Dystrophy, Crystalline, Of Schnyder Corneal Dystrophy, Schnyder Type Corneal Dystrophy Crystalline Of Schnyder Crystalline Stromal Dystrophy Hereditary Crystalline Stromal Dystrophy Of Schnyder Scd Corneal Dystrophy, Schnyder Schnyder Crystalline Dystrophy Sine Crystals Dystrophy, Corneal, Crystalline, Schnyder
Parathyroid Gland Disease	Parathyroid Diseases Disease Of Parathyroid Glands Parathyroid Disease
Bartter Disease	Bartter Syndrome Bartter'S Syndrome Aldosteronism With Hyperplasia Of The Adrenal Cortex Hypokalemic Alkalosis With Hypercalciuria Potassium Wasting Juxtaglomerular Hyperplasia With Secondary Aldosteronism Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria Salt-Losing Tubular Disorder, Henle'S Loop Type Salt-Wasting Tubulopathy, Henle'S Loop Type Bartters Syndrome
Vertigo, Benign Recurrent	Benign Paroxysmal Positional Vertigo Bppv Vestibulopathy, Familial BRV Vertigo, Benign Paroxysmal Positional Benign Paroxysmal Positional Nystagmus Benign Recurrent Vertigo Familial Benign Recurrent Vertigo Familial Vestibulopathy Benign Paroxysmal Nystagmus Bppv - [Benign Positional Paroxysmal Vertigo]
Pseudohypoparathyroidism, Type Ib	Pseudohypoparathyroidism Type 1b PHP1B Pseudohypoparathyroidism Ib Pseudohypoparathyroidism Type Ib Php Ib Pseudohypoparathyroidism 1b
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS15125	TRPV5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20121	Trpv5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26625	Trpv5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRPV5	VGNC	VGNC:36401
Macaca mulatta	TRPV5	VGNC	VGNC:81783
Mus musculus	TRPV5	MGD	MGI:2429764
Felis catus	TRPV5	VGNC	VGNC:66599
Canis familiaris	TRPV5	VGNC	VGNC:47885
Rattus norvegicus	TRPV5	RGD	RGD:620636
Others	TRPV5	NCBI