EOMES - eomesodermin Gene

Also Known as TBR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8320

About EOMES

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:27,715,953-27,722,713 (from NCBI)

This gene has 3 transcripts (splice variants), 299 orthologues, 16 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 5.9), spleen (RPKM 5.3) and 10 other tissues.

Summary

This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

EOMES Products (3)

mRNA	Protein	Name
NM_001278182.2	NP_001265111.1	eomesodermin homolog isoform 1
NM_001278183.2	NP_001265112.1	eomesodermin homolog isoform 3
NM_005442.4	NP_005433.2	eomesodermin homolog isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20713518	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in CD8-positive, alpha-beta T cell differentiation involved in immune response	IMP IMP: Inferred from mutant phenotype	17566017	GOA
involved in brain development	IMP IMP: Inferred from mutant phenotype	17353897	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20713518	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EOMES Protein Structure

T-box

0
200
400
600
686 a.a.

Protein Preferred Names	Protein Names
eomesodermin homolog	T-box brain protein 2

EOMES Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P87101	TBR2 Antibody (YA6794)	WB, IHC-P, IHC-F	Human, Mouse

Related Diseases

Diseases	Alias
Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome
Bilateral Polymicrogyria
Polymicrogyria	Pmg
Type 1 Diabetes Mellitus 21	Diabetes Mellitus, Insulin-Dependent, 21 Iddm21 T1D21 Insulin-Dependent Diabetes Mellitus 21
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Periventricular Nodular Heterotopia	Periventricular Heterotopia Pvnh Familial Nodular Heterotopia Heterotopia, Periventricular Periventricular Heterotopia, X-Linked
Band Heterotopia	Subcortical Band Heterotopia Double Cortex Syndrome Subcortical Laminar Heterotopia Double Cortex Band Heterotopia Of Brain BH Heco Heterotopic Cortex Familial Band Heterotopia Dc Dc Syndrome Heterotopia, Subcortical Band Sbh Sclh Bhy
Polymicrogyria, Bilateral Perisylvian, X-Linked	Bilateral Perisylvian Polymicrogyria Polymicrogyria, Bilateral Perisylvian Pmgx Perisylvian Syndrome, Congenital Bilateral Cbps Congenital Bilateral Perisylvian Syndrome Perisylvian Syndrome BPPX Bpp
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS04404	EOMES Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19679	Eomes Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26172	Eomes Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EOMES	VGNC	VGNC:61888
Bos taurus	EOMES	VGNC	VGNC:28516
Macaca mulatta	EOMES	VGNC	VGNC:110368
Rattus norvegicus	EOMES	RGD	RGD:1359706
Mus musculus	EOMES	MGD	MGI:1201683
Canis familiaris	EOMES	VGNC	VGNC:40389