SHKBP1 - SH3KBP1 binding protein 1 Gene

Also Known as Sb1; PP203

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 92799

About SHKBP1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,576,873-40,591,397 (from NCBI)

This gene has 28 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 24.5), spleen (RPKM 23.9) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in lysosome. [provided by Alliance of Genome Resources, Apr 2022]

SHKBP1 Products (1)

mRNA	Protein	Name
NM_138392.4	NP_612401.2	SH3KBP1-binding protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Referencias	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21145461	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHKBP1 Protein Structure

BTB_2

0
200
400
600
707 a.a.

Protein Preferred Names	Protein Names
SH3KBP1-binding protein 1	SETA-binding protein 1

SHKBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	SHKBP1	Q8TBC3	LXN	Homo sapiens	Q9BS40	Validated Y2H	32296183
Intra	SHKBP1	Q8TBC3	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	SHKBP1	Q8TBC3	CUL3	Homo sapiens	Q13618	Y2H	21988832
Intra	SHKBP1	Q8TBC3	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
Intra	SHKBP1	Q8TBC3	SHKBP1	Homo sapiens	Q8TBC3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SHKBP1 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P810057	SHKBP1 Antibody (YA9401)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Korean Hemorrhagic Fever	Hemorrhagic Fever With Renal Syndrome
Amelogenesis Imperfecta, Type If	Amelogenesis Imperfecta Type 1f AI1F Amelogenesis Imperfecta, Hypoplastic Type If Amelogenesis Imperfecta Type If Amelogenesis Imperfecta Hypoplastic Type If Amelogenesis Imperfecta 1f
Noonan Syndrome 12	NS12
Dieulafoy Lesion	Dieulafoy'S Lesion Dieulafoy Lesion Of Intestine Dieulafoy Lesion Of Stomach And Duodenum Dieulafoy Disease Exulceratio Simplex Dieulafoy Dieulafoy'S Vascular Malformation
Small Intestine Neuroendocrine Neoplasm	Small Intestine Neuroendocrine Tumor Neuroendocrine Tumor Of The Small Intestine Net Of The Small Intestine Neuroendocrine Neoplasm Of The Small Intestine Neuroendocrine Tumor Of Small Bowel Small Intestinal Neuroendocrine Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS12872	SHKBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SHKBP1	VGNC	VGNC:46149
Mus musculus	SHKBP1	MGD	MGI:2385803
Rattus norvegicus	SHKBP1	RGD	RGD:1309281
Felis catus	SHKBP1	VGNC	VGNC:65126
Macaca mulatta	SHKBP1	VGNC	VGNC:77272
Bos taurus	SHKBP1	VGNC	VGNC:34602
Others	SHKBP1	NCBI