Foxn1 - forkhead box N1 Gene

Mus musculus

Also known as nu; Whn; nude; Fkh19; Hfh11; HFH-11; D11Bhm185e

Gene ID: 15218 | Gene type: protein coding

About Foxn1

Summary

The protein encoded by this gene is part of the forkhead family or "winged-helix" transcription factors that are important in developmental processes, immune system regulation, metabolism, Cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]

Foxn1 Products(2)

mRNA	Protein	Name
NM_001277290.1	NP_001264219.1	forkhead box protein N1 isoform 2
NM_008238.2	NP_032264.1	forkhead box protein N1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9108066	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	9108066	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9108066	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	24184560	MGI
involved in T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	24184560	MGI
involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	19853842	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	22072979	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	21191399	MGI
involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	24184560	MGI
acts upstream of or within keratinocyte differentiation	IDA IDA: Inferred from direct assay	11841548	MGI
acts upstream of or within lymphocyte homeostasis	IMP IMP: Inferred from mutant phenotype	22072979	MGI
involved in lymphoid lineage cell migration into thymus	IMP IMP: Inferred from mutant phenotype	19853842	MGI
acts upstream of or within nail development	IMP IMP: Inferred from mutant phenotype	21191399	MGI
involved in positive regulation of hair follicle development	IMP IMP: Inferred from mutant phenotype	21109991	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9108066	MGI
acts upstream of or within regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	22072979	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17683113	MGI
involved in regulation of positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	24184560	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	22072979	MGI
involved in thymus epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	21109991	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein N1

HNF-3/forkhead homolog 11	hepatocyte nuclear factor 3 forkhead homolog 11
winged-helix transcription factor nude

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05065	FOXN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxn1	NCBI	NCBI:8456

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