Slc22a3 - solute carrier family 22 (organic cation transporter), member 3 Gene

Mus musculus

Also known as EMT; Oct3; Orct3; Slca22a3

Gene ID: 20519 | Gene type: protein coding

About Slc22a3

Summary

Enables neurotransmitter transmembrane transporter activity and quaternary ammonium group transmembrane transporter activity. Involved in dopamine transport; histamine transport; and serotonin transport. Acts upstream of or within several processes, including cation transport; quaternary ammonium group transport; and regulation of appetite. Located in neuronal cell body. Is expressed in several structures, including brain; dermis; extraembryonic component; genitourinary system; and thymus primordium. Orthologous to human SLC22A3 (solute carrier family 22 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a3 Products(1)

mRNA	Protein	Name
NM_011395.2	NP_035525.1	solute carrier family 22 member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoamine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18513366	MGI
enables neurotransmitter transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18513366	MGI
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	10966924	MGI
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: Inferred from direct assay	10966924	MGI
enables transmembrane transporter activity	IDA IDA: Inferred from direct assay	28543680	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in dopamine transport	IMP IMP: Inferred from mutant phenotype	18513366	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	16061728	MGI
acts upstream of or within histamine transport	IMP IMP: Inferred from mutant phenotype	16061728	MGI
involved in histamine transport	IMP IMP: Inferred from mutant phenotype	18513366	MGI
acts upstream of or within histamine uptake	IMP IMP: Inferred from mutant phenotype	16061728	MGI
acts upstream of or within monoamine transport	IMP IMP: Inferred from mutant phenotype	11390648	MGI
acts upstream of or within monocarboxylic acid transport	IMP IMP: Inferred from mutant phenotype	18513366	MGI
acts upstream of or within neurotransmitter transport	IMP IMP: Inferred from mutant phenotype	18513366	MGI
involved in norepinephrine transport	IMP IMP: Inferred from mutant phenotype	18513366	MGI
acts upstream of or within organic cation transport	IDA IDA: Inferred from direct assay	10966924	MGI
acts upstream of or within organic hydroxy compound transport	IMP IMP: Inferred from mutant phenotype	18513366	MGI
acts upstream of or within quaternary ammonium group transport	IDA IDA: Inferred from direct assay	10966924	MGI
acts upstream of or within regulation of appetite	IMP IMP: Inferred from mutant phenotype	15028779	MGI
involved in serotonin transport	IMP IMP: Inferred from mutant phenotype	18513366	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15817714	MGI
located in endomembrane system	IDA IDA: Inferred from direct assay	27659446	MGI
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	27659446	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	18513366	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15817714	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 22 member 3

organic cation transporter 3

solute carrier family 22, member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13074	SLC22A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc22a3	NCBI	NCBI:6581

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