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LYRM4 - LYR motif containing 4 Gene

Also Known as ISD11; CGI-203; COXPD19; C6orf149

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57128

About LYRM4

Cytogenetic location: 6p25.1 Genomic coordinates (GRCh38): 6:5,031,753-5,260,950 (from NCBI)

This gene has 9 transcripts (splice variants), 143 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 2.3), thyroid (RPKM 2.1) and 25 other tissues.

Summary

The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]

LYRM4 Products (5)

mRNA	Protein	Name
NM_001164840.3	NP_001158312.1	LYR motif-containing protein 4 isoform 2
NM_001164841.3	NP_001158313.1	LYR motif-containing protein 4 isoform 3
NM_001318782.1	NP_001305711.1	LYR motif-containing protein 4 isoform 4
NM_001318783.1	NP_001305712.1	LYR motif-containing protein 4 isoform 5
NM_020408.6	NP_065141.3	LYR motif-containing protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18650437	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	29097656	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in [2Fe-2S] cluster assembly	IDA IDA: Inferred from direct assay	17331979	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of mitochondrial [2Fe-2S] assembly complex	IDA IDA: Inferred from direct assay	21298097	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	17331979	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23593335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYRM4 Protein Structure

Complex1_LYR_1

0
91 a.a.

Protein Preferred Names	Protein Names
LYR motif-containing protein 4	homolog of yeast Isd11

LYRM4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LYRM4	Q9HD34	NFS1	Homo sapiens	Q9Y697	Pull Down	26342079
Intra	LYRM4	Q9HD34	NFS1	Homo sapiens	Q9Y697	Anti Tag CoIP	27499296
Intra	LYRM4	Q9HD34	NFS1	Homo sapiens	Q9Y697	Anti Tag CoIP	33961781
Intra	LYRM4	Q9HD34	NFS1	Homo sapiens	Q9Y697	Light Scattering	26342079

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency 19	COXPD19 Severe Neonatal Lactic Acidosis Due To Nfs1-Isd11 Complex Deficiency Combined Oxidative Phosphorylation Deficiency, Type 19
Chromosome 6pter-P24 Deletion Syndrome	6p Subtelomeric Deletion Syndrome 6p25 Microdeletion Syndrome Distal Monosomy 6p Distal Deletion 6p Monosomy 6p25
Friedreich Ataxia	Friedreich Ataxia 1 FRDA Friedreich Ataxia With Retained Reflexes Frda1 Fa Friedreich'S Ataxia Hereditary Spinal Ataxia Fa1 Friedreich'S Tabes Hereditary Spinal Sclerosis Spinocerebellar Ataxia, Friedreich Friedreich Spinocerebellar Ataxia Friedrich'S Ataxia
Combined Oxidative Phosphorylation Deficiency
Multiple Mitochondrial Dysfunctions Syndrome 3	MMDS3 Iba57 Deficiency Multiple Mitochondrial Dysfunctions Syndrome Type 3 Mitochondrial Dysfunctions, Multiple, Syndrome, Type 3
Lactic Acidosis	Acidosis, Lactic Acidosis Lactic
Autosomal Recessive Cerebellar Ataxia	Arca
Hereditary Ataxia	Sca Spinocerebellar Ataxia Ataxias Hereditary Ataxias, Hereditary
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07924	LYRM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LYRM4	VGNC	VGNC:31110
Rattus norvegicus	LYRM4	RGD	RGD:7672286
Mus musculus	LYRM4	MGD	MGI:2683538
Others	LYRM4	NCBI