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SRSF4 - serine and arginine rich splicing factor 4 Gene

Also Known as SFRS4; SRP75

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6429

About SRSF4

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:29,147,743-29,181,900 (from NCBI)

This gene has 8 transcripts (splice variants), 239 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 33.0), bone marrow (RPKM 32.4) and 25 other tissues.

Summary

This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]

SRSF4 Products (1)

mRNA	Protein	Name
NM_005626.5	NP_005617.2	serine/arginine-rich splicing factor 4

SRSF4 Protein Structure

RRM_1

0
100
200
300
400
494 a.a.

Protein Preferred Names	Protein Names
serine/arginine-rich splicing factor 4	SR splicing factor 4

SRSF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRSF4	Q08170	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	SRSF4	Q08170	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	SRSF4	Q08170	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	SRSF4	Q08170	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	SRSF4	Q08170	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	SRSF4	Q08170	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	SRSF4	Q08170	TRA2B	Homo sapiens	P62995	Y2H Prey Pooling	32296183
Intra	SRSF4	Q08170	TRA2B	Homo sapiens	P62995	Y2H Array	32296183
Intra	SRSF4	Q08170	SRSF6	Homo sapiens	Q13247	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13795	SRSF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22831	Srsf4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SRSF4	VGNC	VGNC:46820
Mus musculus	SRSF4	MGD	MGI:1890577
Bos taurus	SRSF4	VGNC	VGNC:35302
Rattus norvegicus	SRSF4	RGD	RGD:1561347
Macaca mulatta	SRSF4	VGNC	VGNC:100150
Felis catus	SRSF4	VGNC	VGNC:65696
Others	SRSF4	NCBI