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Mfsd2a - MFSD2 lysolipid transporter A, lysophospholipid Gene

Also Known as NLS1; Mfsd2; 1700018O18Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 76574

Summary

Enables fatty acid transmembrane transporter activity; lysophosphatidylcholine flippase activity; and lysophospholipid:sodium symporter activity. Involved in central nervous system development; lipid transport; and transcytosis. Acts upstream of or within several processes, including photoreceptor cell development; regulation of lipid metabolic process; and retina development in camera-type eye. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 15. Orthologous to human MFSD2A (major facilitator superfamily domain containing 2A). [provided by Alliance of Genome Resources, Apr 2022]

Mfsd2a Products (1)

mRNA	Protein	Name
NM_029662.2	NP_083938.2	sodium-dependent lysophosphatidylcholine symporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fatty acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	24828044	MGI
enables long-chain fatty acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	27008858	MGI
enables lysophosphatidylcholine flippase activity	IDA IDA: Inferred from direct assay	26945070	MGI
enables lysophospholipid:sodium symporter activity	IDA IDA: Inferred from direct assay	24828044	MGI
enables symporter activity	IMP IMP: Inferred from mutant phenotype	24828044	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of brain development	IMP IMP: Inferred from mutant phenotype	30074985	MGI
acts upstream of or within cellular response to starvation	IMP IMP: Inferred from mutant phenotype	23209793	MGI
NOT involved in embryonic brain development	IMP IMP: Inferred from mutant phenotype	30074985	MGI
acts upstream of or within energy homeostasis	IMP IMP: Inferred from mutant phenotype	23209793	MGI
NOT involved in establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	27008858	MGI
involved in establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	24828040	MGI
NOT involved in establishment of blood-retinal barrier	IMP IMP: Inferred from mutant phenotype	27008858	MGI
involved in fatty acid transport	IMP IMP: Inferred from mutant phenotype	24828044	MGI
involved in hippocampus development	IDA IDA: Inferred from direct assay	24828044	MGI
involved in lipid transport across blood-brain barrier	IMP IMP: Inferred from mutant phenotype	24828044	MGI
involved in long-chain fatty acid transport	IMP IMP: Inferred from mutant phenotype	27008858	MGI
involved in lysophospholipid transport	IDA IDA: Inferred from direct assay	24828044	MGI
involved in lysophospholipid transport	IMP IMP: Inferred from mutant phenotype	26005868	MGI
acts upstream of or within maintenance of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	30074985	MGI
acts upstream of or within motor behavior	IMP IMP: Inferred from mutant phenotype	23209793	MGI
acts upstream of or within negative regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	23209793	MGI
acts upstream of or within photoreceptor cell morphogenesis	IMP IMP: Inferred from mutant phenotype	27008858	MGI
acts upstream of or within photoreceptor cell outer segment organization	IMP IMP: Inferred from mutant phenotype	27008858	MGI
acts upstream of or within positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	23209793	MGI
acts upstream of or within positive regulation of triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	23209793	MGI
acts upstream of regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	30074985	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	23209793	MGI
acts upstream of regulation of neuron projection arborization	IMP IMP: Inferred from mutant phenotype	30074985	MGI
acts upstream of regulation of phosphatidylcholine metabolic process	IMP IMP: Inferred from mutant phenotype	30074985	MGI
acts upstream of regulation of phosphatidylethanolamine metabolic process	IMP IMP: Inferred from mutant phenotype	30074985	MGI
acts upstream of regulation of phosphatidylserine metabolic process	IMP IMP: Inferred from mutant phenotype	30074985	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	27008858	MGI
acts upstream of or within retinal pigment epithelium development	IMP IMP: Inferred from mutant phenotype	27008858	MGI
involved in transcytosis	IMP IMP: Inferred from mutant phenotype	24828040	MGI
acts upstream of or within very-low-density lipoprotein particle assembly	IMP IMP: Inferred from mutant phenotype	23209793	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	23209793	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	24828040	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sodium-dependent lysophosphatidylcholine symporter 1	major facilitator superfamily domain containing 2 major facilitator superfamily domain containing 2A major facilitator superfamily domain-containing protein 2A sodium-dependent LPC symporter 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08391	MFSD2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-164994	LysoPC (18:4(6Z,9Z,12Z,15Z))		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mfsd2a	NCBI	NCBI:84879