2. Gene
  3. Slc12a2 - solute carrier family 12 member 2 Gene

Slc12a2 - solute carrier family 12 member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bsc2; Nkcc1

Gene ID: 83629 | Gene type: protein coding

About Slc12a2

Summary

Enables sodium:potassium:chloride symporter activity. Involved in several processes, including chloride transport; metal ion transport; and positive regulation of cell volume. Acts upstream of or within gamma-aminobutyric acid signaling pathway and regulation of spontaneous synaptic transmission. Located in cytosol and plasma membrane. Used to study hypertension; middle cerebral artery infarction; and visual epilepsy. Biomarker of hypertension; sensorineural hearing loss; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 78. Orthologous to human SLC12A2 (solute carrier family 12 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a2 Products(1)

mRNA Protein Name
NM_031798.2 NP_113986.2 solute carrier family 12 member 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables sodium:potassium:chloride symporter activity IMP
IMP: Inferred from mutant phenotype
12556450 RGD
Biological Process GO Annotation Evidence Reference Source
involved in chloride transport IMP
IMP: Inferred from mutant phenotype
12556450 RGD
involved in gamma-aminobutyric acid signaling pathway IEP
IEP: Inferred from expression pattern
15090604 RGD
acts upstream of or within gamma-aminobutyric acid signaling pathway IMP
IMP: Inferred from mutant phenotype
16227993 RGD
involved in hyperosmotic response IMP
IMP: Inferred from mutant phenotype
15284343 RGD
involved in positive regulation of cell volume IMP
IMP: Inferred from mutant phenotype
15284343 RGD
involved in potassium ion transport IMP
IMP: Inferred from mutant phenotype
12556450 RGD
acts upstream of or within regulation of spontaneous synaptic transmission IMP
IMP: Inferred from mutant phenotype
16227993 RGD
involved in sodium ion transport IMP
IMP: Inferred from mutant phenotype
12556450 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 12 member 2

solute carrier family 12 (sodium/potassium/chloride transporter), member 2

solute carrier family 12 (sodium/potassium/chloride transporters), member 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12997 SLC12A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc12a2 NCBI NCBI:6558