2813319-14-9
Chemical Structure
Antitumor photosensitizer-11
- CAS No.: 2813319-14-9
- Formula:C28H22IN3O2
- Molecular Weight:559.40
InChIKey: PIYWANIJFLLYTL-UHFFFAOYSA-M
SMILES: CCN1C2=CC=C([N+]([O-])=O)C=C2C3=C1C=CC(/C=C/C4=[N+](C)C5=CC=CC6=CC=CC4=C56)=C3.[I-]
Biological Activity: Antitumor photosensitizer-11 is a type-I carbazole/benzindolium photosensitizer with antitumor activity. Antitumor photosensitizer-11 induces ROS generation via a type-I pathway, forming superoxide anions and hydroxyl radicals. Antitumor photosensitizer-11 triggers immunogenic cell death in cancer cells via enhanced oxidative stress. Antitumor photosensitizer-11 exhibits antiproliferative activity in normoxic and hypoxic environments, inhibits breast cancer tumor growth in vivo, and promotes dendritic cell maturation and T cell infiltration. Antitumor photosensitizer-11 can be used for the research of cancer, such as breast cancer[1].
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Antitumor photosensitizer-11 | Antitumor photosensitizer-11 is a type-I carbazole/benzindolium photosensitizer with antitumor activity. Antitumor photosensitizer-11 induces ROS generation via a type-I pathway, forming superoxide anions and hydroxyl radicals. Antitumor photosensitizer-11 triggers immunogenic cell death in cancer cells via enhanced oxidative stress. Antitumor photosensitizer-11 exhibits antiproliferative activity in normoxic and hypoxic environments, inhibits breast cancer tumor growth in vivo, and promotes dendritic cell maturation and T cell infiltration. Antitumor photosensitizer-11 can be used for the research of cancer, such as breast cancer. | |||||||||||||||||||||
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Keywords
