VGLL1 - vestigial like family member 1 Gene

Also Known as TDU; VGL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51442

About VGLL1

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:136,532,215-136,556,799 (from NCBI)

This gene has 4 transcripts (splice variants), 104 orthologues and 2 paralogues. Restricted expression toward placenta (RPKM 103.1).

Summary

The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. [provided by RefSeq, Sep 2009]

VGLL1 Products (1)

mRNA Protein Name
NM_016267.4 NP_057351.1 transcription cofactor vestigial-like protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VGLL1 Protein Structure

Vg_Tdu

Vg_Tdu: Vestigial/Tondu family (21 - 52)

  • 0
  • 100
  • 200
  • 258 a.a.
Protein Preferred Names Protein Names

transcription cofactor vestigial-like protein 1

  • TONDU

VGLL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VGLL1 Q99990 TEAD3 Homo sapiens Q99594
Y2H Prey Pooling
32296183
Intra
VGLL1 Q99990 TEAD3 Homo sapiens Q99594
Y2H Array
32296183
Intra
VGLL1 Q99990 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

VGLL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89740 Vgl-1 Antibody (YA9084) WB, IP, ELISA human

Related Diseases

Diseases Alias
46,Xy Sex Reversal 8

  • SRXY8

  • Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase

  • Tdd

  • 46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency

  • 46xy Sex Reversal 8

  • 46xy Sex Reversal 8, Modifier Of

  • Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase
Sveinsson Chorioretinal Atrophy

  • SCRA

  • Atrophia Areata

  • Helicoid Peripapillary Chorioretinal Degeneration

  • Hpcd

  • Aa

  • Peripapillary Chorioretinal Degeneration, Icelandic Type

  • Helicoidal Peripapillary Chorioretinal Degeneration

  • Atrophy, Chorioretinal, Sveinsson
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15644 VGLL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VGLL1 VGNC VGNC:56958
Felis catus VGLL1 VGNC VGNC:82514
Mus musculus VGLL1 MGD MGI:2655768
Canis familiaris VGLL1 VGNC VGNC:48257
Rattus norvegicus VGLL1 RGD RGD:1564038
Others VGLL1 NCBI