Ptafr - platelet-activating factor receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58949

About Ptafr

Primary_assembly 5: 144,765,976-144,795,251 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 223 orthologues, 6 paralogues and is associated with 21 phenotypes. Biased expression in Spleen (RPKM 63.9), Lung (RPKM 25.3) and 9 other tissues.

Summary

Enables mitogen-activated protein kinase binding activity and platelet activating factor receptor activity. Involved in several processes, including positive regulation of gene expression; positive regulation of transport; and regulation of cellular extravasation. Located in plasma membrane. Used to study several diseases, including acute kidney failure; neutropenia; perinatal necrotizing enterocolitis; pleurisy; and transient cerebral ischemia. Biomarker of conjunctivitis; sciatic neuropathy; and transient cerebral ischemia. Orthologous to human PTAFR (platelet activating factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ptafr Products (1)

mRNA Protein Name
NM_053321.2 NP_445773.1 platelet-activating factor receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables mitogen-activated protein kinase binding IDA
IDA: Inferred from direct assay
23911909 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23911909 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9495811 RGD
involved in cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
IEP: Inferred from expression pattern
9321918 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
2170386 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
17515866 RGD
involved in cellular response to gravity IEP
IEP: Inferred from expression pattern
15659787 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
3019921 RGD
involved in parturition IMP
IMP: Inferred from mutant phenotype
1849751 RGD
involved in positive regulation of cellular extravasation IMP
IMP: Inferred from mutant phenotype
2829894 RGD
involved in positive regulation of gastro-intestinal system smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
10821044 RGD
involved in positive regulation of inositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
8798508 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
11779582 RGD
involved in positive regulation of leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8592427 RGD
involved in positive regulation of leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
10528212 RGD
involved in positive regulation of maternal process involved in parturition IMP
IMP: Inferred from mutant phenotype
1849751 RGD
involved in positive regulation of neutrophil degranulation IMP
IMP: Inferred from mutant phenotype
2829894 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
8216700 RGD
involved in positive regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
10821044 RGD
involved in positive regulation of transcytosis IMP
IMP: Inferred from mutant phenotype
9664076 RGD
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
8216700 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
2545780 RGD
involved in positive regulation of voltage-gated chloride channel activity IDA
IDA: Inferred from direct assay
8168510 RGD
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10482285 RGD
involved in response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
IEP: Inferred from expression pattern
9065783 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
10447766 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9065783 RGD
involved in response to organophosphorus IEP
IEP: Inferred from expression pattern
9321918 RGD
involved in response to symbiotic bacterium IEP
IEP: Inferred from expression pattern
10447766 RGD
involved in transcytosis IMP
IMP: Inferred from mutant phenotype
9664076 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet-activating factor receptor

  • PAF-R

  • PAFr

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11347 PTAFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11348 Ptafr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11349 Ptafr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptafr NCBI NCBI:5724