2. Gene
  3. PTAFR - platelet activating factor receptor Gene

PTAFR - platelet activating factor receptor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PAFR

Gene ID: 5724 | Gene type: protein coding

About PTAFR

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,147,166-28,193,856 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues and 6 paralogues. Broad expression in appendix (RPKM 15.7), bone marrow (RPKM 12.4) and 19 other tissues.

Summary

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including Phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

PTAFR Products(4)

mRNA Protein Name
NM_001164722.3 NP_001158194.1 platelet-activating factor receptor
NM_000952.5 NP_000943.1 platelet-activating factor receptor
NM_001164723.3 NP_001158195.1 platelet-activating factor receptor
NM_001164721.2 NP_001158193.1 platelet-activating factor receptor

PTAFR Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (33 - 293)

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  • 300
  • 342 a.a.
Protein Preferred Names Protein Names

platelet-activating factor receptor

PAF-R

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Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11347 PTAFR Human Pre-designed siRNA Set A / Unkown
HY-RS11348 Ptafr Mouse Pre-designed siRNA Set A / Unkown
HY-RS11349 Ptafr Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PTAFR VGNC VGNC:76461
Rattus norvegicus PTAFR RGD RGD:61897
Bos taurus PTAFR VGNC VGNC:33488
Felis catus PTAFR VGNC VGNC:69132
Mus musculus PTAFR MGD MGI:106066
Canis familiaris PTAFR VGNC VGNC:45129