Pectolinarigenin Induces Mitochondrion-dependent Apoptosis, Causes G2/M Arrest, and Inhibits Migration and Invasion in Rheumatoid Arthritis-Fibroblast-like Synoviocytes

  • J Physiol Investig. 2026 Jan 1;69(1):42-56. doi: 10.4103/ejpi.EJPI-D-25-00047.
Bing Zhang  1 ,  Nan Wu  2  3  4 ,  Ying-Hua Luo  5 ,  Yan-Jun Tang  2 ,  Yan-Zhi Liu  2  3  4 ,  Cheng-Hao Jin  3  4 ,  Zhi-Gang Wang  1  6
Affiliations
  • 1. Department of Biochemistry and Molecular Biology, College of Medical Laboratory Science and Technology, Harbin Medical University, Daqing Campus, Daqing, China.
  • 2. Department of Food Science and Engineering, College of Food Sciences, Heilongjiang Bayi Agricultural University, Daqing, China.
  • 3. Department of Biochemistry and Molecular Biology, College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing, China.
  • 4. National Coarse Cereals Engineering Research Centre, Daqing, China.
  • 5. Department of Grass Science, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.
  • 6. Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, Guangdong, China.
PMID: 41606826 DOI: 10.4103/ejpi.EJPI-D-25-00047
Keywords
Fibroblast-like synoviocyte plasticity; mitochondrial apoptosis sensitizer; multitarget phytochemical; pectolinarigenin; rheumatoid arthritis.
Products