1. Epigenetics
    Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. Histone Acetyltransferase
    Epigenetic Reader Domain
    EGFR

NSC 228155 

Cat. No.: HY-101084 Purity: >98.0%
Handling Instructions

NSC 228155 is a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM. NSC 228155 binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR.

For research use only. We do not sell to patients.

NSC 228155 Chemical Structure

NSC 228155 Chemical Structure

CAS No. : 113104-25-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 490 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

NSC 228155 is a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM[1]. NSC 228155 binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[2].

IC50 & Target

IC50: 0.36 μM (KIX-KID)[1]

In Vitro

NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with IC50s of 2.09 and 6.14 μM, respectively[1].
NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells[1].
NSC 228155 (100 μM) enhances EGFR tyrosine phosphorylation via action of SOD1[2].

References
Molecular Weight

290.25

Formula

C₁₁H₆N₄O₄S

CAS No.

113104-25-9

SMILES

[O-][N+]1=CC=CC=C1SC2=CC=C([N+]([O-])=O)C3=NON=C32

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
NSC 228155
Cat. No.:
HY-101084
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NSC 228155

Cat. No.: HY-101084