113104-25-9
113104-25-9
Chemical Structure
NSC 228155
- CAS No.: 113104-25-9
- Formula:C11H6N4O4S
- Molecular Weight:290.25
IUPAC Name: 2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)pyridine 1-oxide
InChIKey: ICCFXXDUYSPKOL-UHFFFAOYSA-N
SMILES: [O-][N+]1=CC=CC=C1SC2=CC=C([N+]([O-])=O)C3=NON=C32
Biological Activity: NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NSC 228155 | 99.58% | NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM. | ||||||||||||||||||||
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NSC 228155 (Standard) | ≥98% | NSC 228155 (Standard) is the analytical standard of NSC 228155 (HY-101084). This product is intended for research and analytical applications. NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM. | ||||||||||||||||||||
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References
- [1]. Sakanyan V, et al. Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci Rep. 2016 Feb 17;6:21088. [Content Brief]
- [2]. Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5. [Content Brief]
Keywords
