5 Results for "

comet

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "comet" in MCE Product Catalog:

Apcin-A
Apcin-A
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Cat. No.: HY-130841
CAS No.: 1683617-62-0
Purity:  ≥98.0%
Target:  

APC Ligands for Target Protein for PROTAC

Research Areas:  

Cancer

Apcin-A is a small molecule inhibitor that selectively targets the cell division cycle protein Cdc20 and is a derivative of Apcin (HY-110287). Apcin-A competitively binds to the D-box binding pocket of Cdc20 and inhibits substrate ubiquitination mediated by the anaphase promoting complex APC/C-Cdc20. Apcin-A also blocks the binding of Cdc20 to substrates (such as securin and cyclin B1), inhibiting anaphase initiation and cell cycle exit. Apcin-A can promote or prolong mitotic slippage in coordination with p31 comet under conditions of high spindle assembly checkpoint (SAC) activity. Apcin-A can be used to develop anti-mitotic drugs and overcome tumor chemotherapy resistance. Apcin-A can be used to synthesize PROTAC CP5V (HY-130257)[1][2][3].
Chloridazon
Chloridazon
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Cat. No.: HY-W103488
CAS No.: 1698-60-8
Target:  

Environmental Pollutants Herbicide

Research Areas:  

Others

Chloridazon is a herbicide with an LD50 value of 76.6 ppm at genotoxicity assay .
BG14
BG14
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Cat. No.: HY-120106
CAS No.: 1628784-50-8
Target:  

HDAC

Research Areas:  

Others

BG14 is a chemical optical modulation of epigenetic regulation of transcription (COMET) probe. BG14 enables high-resolution optical control of epigenetic mechanisms using visible light and can photochromically inhibit human histone deacetylases (HDACs). BG14 can be used to study the dynamic regulation of the human genome .
Perfluoroundecanoic acid (Standard)
Perfluoroundecanoic acid (Standard)
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Cat. No.: HY-W142432R
CAS No.: 2058-94-8
Target:  

Reference Standards Biochemical Assay Reagents

Research Areas:  

Others

Perfluoroundecanoic acid (Standard) is the analytical standard of Perfluoroundecanoic acid. This product is intended for research and analytical applications. Perfluoroundecanoic acid is an orally active inducer of oxidative stress and DNA damage. Perfluoroundecanoic acid exhibits genotoxicity and reproductive toxicity in swiss mice. Perfluoroundecanoic acid is utilized as a processing aid in the manufacture of fluoropolymer for its thermal and pressure stability, and properties of having both water-repellent and oil-repellent groups and hydrophilic groups on the same molecule .
5,6-Epoxyretinyl palmitate
5,6-Epoxyretinyl palmitate
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Cat. No.: HY-W720550
CAS No.: 3012-64-4
Synonyms: 5,6-Epoxy-RP
Target:  

DNA/RNA Synthesis Drug Metabolite

Research Areas:  

Cancer

5,6-Epoxyretinyl palmitate (5,6-Epoxy-RP) is one of the main photodegradation products of Retinyl palmitate (HY-B1384) produced under UVA light irradiation. 5,6-Epoxyretinyl palmitate exhibits phototoxicity to cells and causes significant DNA single-strand breaks, DNA damage, and chromosomal mutations under light conditions .
Assay Types