401501-66-4
401501-66-4
Chemical Structure
S1R agonist 3
- CAS No.: 401501-66-4
- Formula:C14H20ClNO
- Molecular Weight:253.77
InChIKey: BWNDWNWWUKQCMZ-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C=C1)OCCN2CCC(CC2)C
Biological Activity: S1R agonist 3 is a potent, selective and brain-penetrant sigma-1 receptor (S1R) agonist with a Ki of 1.5 nM. S1R agonist 3 reduces hyperlocomotion in wfs1abKO zebrafish larvae without affecting locomotion in wildtype wfs1abWT zebrafish larvae. S1R agonist 3 reverses Aβ25-35 (HY-P0128)-induced learning and memory impairments. S1R ligand 1 can be used for the research of Alzheimer’s disease[1].
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S1R agonist 3 | S1R agonist 3 is a potent, selective and brain-penetrant sigma-1 receptor (S1R) agonist with a Ki of 1.5 nM. S1R agonist 3 reduces hyperlocomotion in wfs1abKO zebrafish larvae without affecting locomotion in wildtype wfs1abWT zebrafish larvae. S1R agonist 3 reverses Aβ25-35 (HY-P0128)-induced learning and memory impairments. S1R ligand 1 can be used for the research of Alzheimer’s disease. | |||||||||||||||||||||
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References
Keywords
