Pard6a - par-6 family cell polarity regulator alpha Gene

Also Known as Par6a; Par-6a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 307799

Summary

The protein encoded by this gene is a component of the partitioning defective complex, a protein complex involved in controlling epithelial cell polarity as well as Other cell processes. In rat testis cells, the protein localizes to the apical ectoplasmic specialization at the Sertoli-elongating spermatid interface and at the blood-testis barrier. Accordingly, knockdown of this gene in Sertoli cell epithelia results in compromised blood-testis barrier integrity. Knockdown of this gene in various neuronal cell types results in a variety of phenotypes including abnormal dendritic spine morphogenesis and defective axon outgrowth to the spinal midline. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Pard6a Products (3)

mRNA Protein Name
NM_001003653.3 NP_001003653.2 partitioning defective 6 homolog alpha isoform 1
NM_001003654.3 NP_001003654.2 partitioning defective 6 homolog alpha isoform 2
NM_001399176.1 NP_001386105.1 partitioning defective 6 homolog alpha isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12610628 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of cellular localization IMP
IMP: Inferred from mutant phenotype
18621709 RGD
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
15090620 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15090620 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
18621709 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

partitioning defective 6 homolog alpha

  • PAR-6 alpha

  • par-6 (partitioning defective 6,) homolog alpha

  • partitioning defective protein 6A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10038 PARD6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pard6a NCBI NCBI:50855